Wearable Device for Real-Time Prevention of Freezing-of-Gait in Parkinson’s Disease
Objective: In our previous work, we developed machine learning models to predict and detect freezing-of-gait (FOG) [1]. In this study, we aimed to use those…How many days are required to reliably estimate diverse digital mobility outcomes from various gait domains with a lower back sensor in people with Parkinson’s disease?
Objective: To determine the number of days needed to obtain reliable, diverse digital mobility outcomes (DMOs) from daily activity recordings obtained using a lower back,…Examining and contextualizing free-living heart rate using multiple wearable sensors: a potential approach for assessing autonomic dysfunction in Parkinson’s disease?
Objective: To examine context-specific fluctuations in free-living heart rate (HR) across a week-long multi-sensor wear period in people with Parkinson’s disease (PD). Background: Non-motor symptoms,…Distinguishing Parkinson’s disease from atypical Parkinsonian syndrome using multistage deep learning based on dopamine transporter imaging
Objective: We made the diagnostic model using a deep learning algorithm based on dopamine transporterWe made the diagnostic model using a deep learning algorithm based…4-Aminopyridine improves downbeat nystagmus in SCA27b: A case report
Objective: To assess objective clinical improvement in video-oculography in a patient with SCA27b on 4-aminopyridine (4-AP) treatment. Background: Spinocerebellar ataxia 27b (SCA27b; MIM 620174) is…NGS diagnosis rate in a combined cerebellar ataxia and spastic paraplegia series from southern Spain
Objective: To evaluate the diagnosis rate of Next Generation Sequencing (NGS) in a combined series of patients with progressive cerebellar ataxia (CA) and progressive spastic…Expanding the Phenotype of a Novel Mutation in ELOVL4 and the Differential Diagnosis of the Hot Cross Bun Sign
Objective: To describe the clinical and radiological characteristics of three independent families affected by SCA 34 due to a recently identified mutation in ELOVL4. Background:…Progressive Apraxia of Speech as a Presenting Symptom of Spinocerebellar Ataxia Type 2
Objective: To describe a spinocerebellar ataxia (SCA) presenting with progressive apraxia of speech (AOS), a previously undescribed SCA phenotype. Background: Spinocerebellar ataxia type 2 (SCA2)…Spectrum of Non-HD Hereditary Chorea- Case Series from An Indian Movement Disorder Centre
Objective: To identify and characterize the hereditary chorea other than Huntington’s disease (HD) in an Indian movement disorder clinic. Background: Approximately 1-3% of HD phenotypes…A Phase IIb Double-Blind Placebo-Controlled Randomized Cross-Over Clinical Trial of Sodium Oxybate in Isolated Focal Laryngeal Dystonia
Objective: A phase IIb double-blind, placebo-controlled, cross-over, randomized clinical trial of a single dose of sodium oxybate investigated the efficacy and safety of the drug…
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