Longitudinal Changes in Quality of Life After Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease
Objective: To clarify longitudinal changes in QOL in PD after STN-DBS. Background: While it is well known that motor complications are dramatically improved after subthalamic…Identifying the Most Sensitive Patient-reported Items from the MDS-UPDRS that Predict Initiation of PD Medications in Early Disease
Objective: Objective: To determine the most sensitive combination of MDS-UPDRS Parts IB and II items that accurately predicted the clinically relevant target of dopaminergic therapy…The Impact of VPS35 D620N Mutation on Alternative Autophagy and its Reversal by Estrogen in Parkinson’s Disease
Objective: We investigated the relationship between alternative autophagy and VPS35 D620N mutant-related PD pathogenesis. Background: VPS35 is critically involved in the mechanisms of neurodegeneration observed…Interaction of GCase and ganglioside GM1 in the aggregation of α-Synuclein
Objective: The objective of this work is to investigate the relationship between ganglioside GM1 levels and α-synuclein aggregation in the context of GBA1 mutations. Background:…LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Pathologic Alpha-Synuclein: Clinical and Biomarker Characterization
Objective: To compare clinical and biomarker features and rate of progression among LRRK2-associated parkinsonism cases with and without in vivo evidence of pathologic alpha-synuclein (asyn)…Cross-Omics Clustering Identifies Common Molecular Patterns in Parkinson’s Disease
Objective: Uncover novel molecular signatures to define Parkinson's disease (PD) patients' clusters using multi-omics integration and evaluate clinical and neuroimaging data. Background: PD is a…Ultrasound of Spinal Fluid Dynamics in Headache and Vertigo Patients with Central Sensitization: Novel Biomarker
Objective: This study aimed to investigate the neurophysiological responses and potential mechanisms underlying the therapeutic effects of ultrasound (US)-guided dry needling in patients presenting with…The dementia with Lewy bodies related metabolic brain pattern (DLBRP) – a multicentric validation
Objective: Dementia with Lewy bodies-related pattern (DLBRP) has been identified from the FDG PET brain imaging of DLB patients and healthy controls previously. A multicentric…Increased Brain Free Water is Associated with Regional Gene Expression in Parkinson’s Disease
Objective: In this study, we used brain free water scores and regional gene expression profiles from the Allen Human Brain Atlas transcriptomic data to investigate…Microstructural Changes in the Inferior Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disease
Objective: Identify neuroimaging correlates of excessive daytime sleepiness in Lewy body disorders using diffusion MRI. Background: Excessive daytime sleepiness (EDS) is a common and disabling…
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