Sustained Chorea Improvements with Long-Term, Once-Daily Valbenazine in Adults with Huntington’s Disease
Objective: To present interim analyses from KINECT®-HD2 (NCT04400331), an ongoing open-label study of once-daily valbenazine (VBZ) for chorea associated with Huntington’s disease (HD). Background: In…Huntington’s Disease Pathogenesis, Molecular Factors, and Potential for Combinatorial Therapies: A Focus on BDNF and NMDA Receptor Therapies
Objective: This paper outlines current therapeutic options for HD, and ultimately suggests taking a combinatorial therapeutic approach to slow HD progression by simultaneously treating multiple…Serum Alpha-Synuclein Levels Are Decreased in Patients with Restless Legs Syndrome and Restored by Intravenous Iron Therapy in Correlation with Ferritin
Objective: To determine potential connection between serum Alpha-synuclein (α-syn) concentrations and restless legs syndrome (RLS), and explore the impact of intravenous (IV) iron supplementation on serum…Impact of Patient Input on the Study Execution of a Prospective, Epidemiological Study
Objective: To demonstrate the direct impact patient input had on the study design and execution of the Epitome study (NCT06055725). Background: It is increasingly accepted…A prospective study on post-stroke Holmes tremor with analysis of semiology, lesion topography and treatment outcomes
Objective: We aimed to (1) estimate incidence of HT following stroke at a tertiary care centre, (2) study and identify patterns of stroke lesions which…Axial Tremor does not correlate with Poor Balance in Essential Tremor
Objective: To explore the correlation between the severity of axial tremor and balance disorder in Essential Tremor (ET). Background: ET is a heterogeneous disorder and…Comparative assessment of cognitive functions of patients with ET and ET plus.
Objective: to conduct a comparative analysis of changes in neurological status and cognitive decline of various types of essential tremor (ET). Background: in the new…Delineating the Molecular and Clinical Spectrum of Epilepsy-Dyskinesia Syndromes in Children (The Epilepsy-Dyskinesia Spectrum Study)
Objective: To understand the spectrum and association of movement and seizure disorders on a clinical and molecular level. Background: Epilepsy-Dyskinesia Syndromes (EDS) are neurological conditions…Clinico- radiological profile of four patients with CSF1R- related leukoencephalopathy: A case series from India
Objective: We aimed to describe the clinical, radiological and genetic profile of patients with CSF1R- related leukoencephalopathy. Background: CSF1R- related leukoencephalopathy is a rare dominantly…Prevalence of Parkinson’s Disease and Possible Parkinsonian Syndrome in Gaucher Disease: Data From the ICGG Gaucher Registry
Objective: To estimate the age-specific risk of Parkinson’s disease (PD) and possible parkinsonian syndrome (pPS) in Gaucher disease (GD) based on registry data. Background: While…
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