Is cathepsin D a good target for therapy in Tau-related conditions?
Objective: To study the involvement of cathepsin D in the pathogenesis of Tau-related conditions. Background: The endo-lysosomal system (ELS) is central in processing of neurodegenerative…Identification of underlying Lewy body pathology in primary tauopathies by α-synuclein seed amplification assay
Objective: To determine intravitam prevalence of α-synuclein (αSyn) pathology in primary tauopathies, such as PSP and CBS, by αSyn seed amplification assay (synSAA) Background: Neuropathological…Early Syndromes and Clinicopathologic Progression in Progressive Supranuclear Palsy
Objective: We aimed to characterize early clinical features of progressive supranuclear palsy (PSP) that might correlate with clinical course and neuropathologic findings. Background: Progressive supranuclear…18F-Florzolotau PET uncovers the Co-pathological Heterogeneity of Tau Protein in Dementia with Lewy Bodies
Objective: We attempted to reveal the topographical deposition patterns of tau proteins in the living brains of patients with DLB in vivo by virtue of…Passive smartphone speech monitoring in isolated rapid eye movement sleep behaviour disorder
Objective: We aimed to design and test the sensitivity of a fully-automated and noise-resistant smartphone-based system that can unobtrusively screen for prodromal parkinsonian speech disorder…Beyond Clinical Presentation: Incorporating Neuroimaging and Biofluid Markers to Predict Progression of Parkinson’s Disease
Objective: To assess whether including measurements of neuroimaging and biofluid-based biomarkers improves predictive ability of models of motor and non-motor progression up to 5-year follow-up…Vestibular impairment, turning direction and turn progression in Parkinson’s disease
Objective: To explore the correlation between the Romberg test condition 4 and turn progression in most affected and least affected body side directions in people…Risk Factors Of Parkinson’s Disease A Case-Control Study In Tunisian Patients
Objective: To investigate the role of family, environmental and professional factors in Parkinson's disease (PD) development. Background: Parkinson's disease (PD) is a neurological disorder with…Exploring Retrospectively the Predisposing Factors of Sleep Disorders in Parkinson’s Disease.
Objective: Identify the predisposing or exacerbating factors of sleep disorders in Parkinson's disease, and examine their association with levodopa treatment. Background: Parkinson's disease (PD) is…Atypical Parkinsonism Secondary to Recurrent Deep Vein Thrombosis with Associated Intracranial Dural Fistula
Objective: This report aims to present a case of atypical parkinsonism that is secondary to recurrent deep vein thrombosis with associated intracranial dural fistula. Background:…
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