Alterations of NAD metabolism in symptomatic and asymptomatic carriers of pathogenic GCH1 variant
Objective: To investigate whether carriers of pathogenic GCH1 variant reveal lower NAD levels in the basal ganglia or the cerebellum compared to variant-free controls. Background:…White matter abnormalities in motor subtypes of Parkinson’s disease
Objective: To evaluate white matter microstructural integrity in Tremor dominant Parkinson’s disease (TDPD) and postural instability and gait disturbance (PIGD) subtypes of PD to ascertain…Longitudinal change in brain function and structure related to plasma neurofilament light protein in early-stage Parkinson’s disease
Objective: We aimed to explore the relationship between the pNfL and change in the brain in early-stage PD using a longitudinal brain imaging cohort. Background:…Differential Diagnosis of Parkinsonism with 18F-FP-CIT PET using a Self-supervised Deep Learning Model
Objective: To develop a self-supervised deep learning model using 18F-FP-CIT PET images from patients with Parkinsonism and to evaluate the model’s performance in the differential…Cholinergic brain vulnerabilities associate with diabetic comorbidity in Parkinson disease
Objective: We aim to explore differences in brain cholinergic nerve terminal integrity between Parkinson's disease (PD) patients with and without comorbid diabetes, utilizing a highly…Enlarged Perivascular Spaces in the Temporal Lobe as a Predictor for Incident Dementia in Parkinson’s Disease
Objective: To evaluate the whether regional burden of enlarged perivascular space (EPVS) hold prognostic value in predicting the dementia conversion in Parkinson's disease (PD). Background:…Cardiac Mitochondrial Complex I Integrity Predicts Axial Symptom Severity in Parkinson’s Disease
Objective: In the present work, we investigated whether cardiac mitochondrial dysfunction might also be associated with the severity of PIGD symptoms in PD patients. Background:…Deep brain stimulation for severe dystonia associated with Wilson’s disease: A prospective multicentre meta-analysis of Nof1 trials
Objective: To assess the efficacy of the deep brain stimulation (DBS) on dystonia in Wilson’s disease (WD). Background: The persistence of disabling dystonia despite medical…Unveiling the Long-term Impact of Unilateral Vim DBS in Essential Tremor
Objective: Our aim is to evaluate the long-term benefit of unilateral VIM DBS. Background: Essential tremor (ET) is the most common movement disorder, and in…Gait Analysis in the 6-Hydroxydopamine Hemiparkinson Rat Model with Deep Brain Stimulation in the Subthalamic nucleus
Objective: The study aims to quantify motor improvement after chronic subthalamic nucleus deep brain stimulation (STN-DBS) in the 6-hydroxydopamine (6-OHDA) hemiparkinson rat model using a…
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