Exercise-induced angiogenesis and midbrain neuroprotection in a mouse model of experimental PD
Objective: The goal of this study is to characterize microvascular changes in the SNpc in response to a neuroprotective bout of exercise. Background: Parkinson’s disease…Single cell transcriptomics of peripheral blood mononuclear cells and associations with clinical outcomes in Parkinson’s disease
Objective: To assess transcriptomics signatures for monocytes and T-cells in different stages of Parkinson’s disease (PD) compared to controls and possible correlations with clinical outcomes.…Distinct Gut Microbiome in Parkinson’s disease Based on the Presence of Premotor Rapid-Eye Movement Sleep Behavior Disorders: Exploring the Alpha-synuclein
Objective: We aim to investigate the microbiome composition and functional profiles in Parkinson’s disease (PD) patients with and without premotor rapid eye movement sleep behavior…Clinical features and brain [18F] FDG PET patterns in patients with progressive supranuclear palsy with and without ventricular dilatation
Objective: To describe the clinical features and the metabolic patterns assessed by the brain [18F] FDG-PET in a cohort of PSP patients with or without…Cortical activity during visually perturbed gait in older adults
Objective: The primary aim of this preliminary study was to explore pre-frontal cortex (PFC) and posterior parietal cortex (PPC) activity in older adults (OAs) during…Early GBA-Related Parkinson’s Disease has a Distinct Clinical Phenotype and Cholinergic Innervation
Objective: This study aims to characterize the clinical features and cholinergic innervation of early Parkinson’s disease (PD) patients with GBA mutations (GBA-PD). Background: The GBA-PD…Habenular Structural Connectivity Changes in Parkinson’s Disease: A 7T MRI Study
Objective: To assess if the structural connectivity of habenula (Hb) differs between Parkinson’s disease (PD) patients and healthy controls (HCs). Background: PD is marked by…Cerebral metabolic network in PLA2G6-associated parkinsonism
Objective: To characterize the cerebral metabolic network in PLA2G6-associated parkinsonism (PLA2G6-P). Background: PLA2G6-associated neurodegeneration is known as a continuum of phenotypes. Patients with late-onset PLA2G6-associated…Cholinergic Basal Forebrain Integrity and Cognition in Parkinson’s Disease
Objective: To examine the association between the integrity of the cholinergic basal forebrain (cBF) and cognition in Parkinson’s disease (PD). Background: Most PD patients experience…MRI Visible Perivascular Spaces are Associated with Disease Duration and Severity in Parkinson’s Disease
Objective: Determine whether enlarged perivascular spaces (ePVS) in Parkinson's disease (PD) is associated with worsening motor symptoms and disease progression. Background: PVS are fluid-filled channels…
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