Istradefylline effects on L-Dopa resistant tremor in Parkinson’s disease
Objective: Quantifying Istradefylline(IST) effects in L-Dopa(LD) resistant tremor in Parkinson’s disease(PD) patients. Background: The adenosine A2A receptors control the indirect pathway. Adenosine A2A receptor activation decreases…Unraveling Plantar Pressure Dynamics in Parkinson’s Disease with Freezing of Gait: Taking Steps through Its Characters and Predictive Factors
Objective: To elucidate plantar pressure characteristics in different stages of PD patients who experienced FOG and identify predictive factors for alterations in plantar pressure parameters.…Adaptive vs Conventional Chronic Deep Brain Stimulation: Results from a Randomized Pilot Trial in Parkinson’s Disease
Objective: To assess the safety and efficacy of chronic adaptive (aDBS) and conventional (cDBS) deep brain stimulation of the subthalamic nucleus in patients with Parkinson’s…Investigation of the Quantitative Impact of T-type Calcium Channels in Subthalamic Nucleus Neurons on Parkinson’s Disease
Objective: Parkinson's disease (PD) might be seen as a classic manifestation of "brain arrhythmias" from a pathological standpoint. This work aims to examine the impact…Dose-dependent alterations of lysosomal activity and alpha-synuclein level in peripheral blood monocyte-derived macrophages and SH-SY5Y neuroblastoma cell line by upon inhibition of mTOR kinase activity
Objective: To evaluate the perceptivity of mTOR kinase activity inhibition for Parkinson's disease therapy (PD). Background: The protein kinase mTOR is currently considered as a…Novel In-Clinic Use of Levodopa Inhalation Powder (CVT-301) as an Outpatient Diagnostic Tool for Parkinson’s Disease
Objective: The clinical diagnosis of PD is based on demonstration of major motor manifestations on the neurologic exam, however, levodopa-responsiveness can be a very helpful…Relationships of blood Vitamin B12 and Homocysteine with Parkinson’s Disease Progression in 3 Contemporary Clinical Trials
Objective: To measure blood levels of vitamin B12 and homocysteine (tHcy) in contemporary clinical trial participants and to determine whether these analytes were associated with…Efficacy of Audiovisual Neuromodulation in the Treatment of Parkinson’s Disease
Objective: To evaluate the AVS effectiveness in depression, anxiety, autonomic disorders and visual dysfunction in PD patients. Background: The severity of non-motor dopa-resistant symptoms in…Clinical Response and Reduction in Medication Use After Deep Brain Stimulation Surgery in a Cohort of Parkinson’s Disease Patients in Colombia
Objective: The objective is to investigate the clinical outcomes and subsequent use of medications in a group of Colombian Patients with DBS Surgery. Background: Parkinson's…Association between statin use and mortality in Parkinson’s disease
Objective: To investigate whether usage of statin is associated with decreased mortality in Parkinson’s disease (PD). Background: Large-scale genome sequencing studies of PD have identified…
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