Rescuing alpha-synuclein toxicity through neuron-specific enhancement of autophagy
Objective: In the present study, we aim to counteract regulatory and transcriptional modifiers of autophagy to enhance neuroprotective proteostasis and rescue alpha-synuclein (asyn) toxicity in…Amygdala-predominant Lewy Body Disease is a Lens for Understanding Pathogenesis and the Alpha-synuclein Seeding Assay in Human Postmortem Brain
Objective: To map alpha-synuclein (asyn) and tau markers in amygdala-predominant Lewy body disease (AP-LBD), identifying spread pathways and vulnerable cell populations. Background: LBD often co-occurs…The differential transcriptomic signatures of substantia nigra in Parkinson disease and Multiple system atrophy
Objective: To investigate transcriptomic signatures of Parkinson's disease (PD) and the Parkinsonian subtype of Multiple System Atrophy (MSA-P) in the substantia nigra pars compacta (SNpc).…Dopamine Transporter Imaging as a Predictor of Functional Outcomes in Parkinson’s Disease
Objective: To evaluate the prognostic value of dopamine transporter (DAT) imaging in predicting future disability, as well as motor and non-motor burden, in Parkinson’s disease…Exploring local gyrification index to understand Parkinson’s disease with mild cognitive impairment
Objective: To investigate correlations between local gyrification index (LGI) and neuropsychological variables in participants with Parkinson's disease (PD) experiencing mild cognitive impairment (PD-MCI). Background: PD…Robust Computation of Subcortical Functional Connectivity Guided by Quantitative Susceptibility Mapping: An Application in Parkinson’s Disease Diagnosis
Objective: In this study, we aimed to introduce and validate a method that incorporates quantitative susceptibility mapping (QSM) into the rs-fMRI analytical pipeline to achieve…First in Class ASO Targeting A53T Allele: Preclinical Efficacy
Objective: Our objective was to develop an antisense oligonucleotide (ASO) allele-specific strategy to target the mutant A53T SNCA allele, reducing aberrant α-synuclein production, without downregulating…Distribution of Genomic Ancestries and Genetic Variation Among Individuals Enrolled in the PD GENEration Study
Objective: To assess the distribution of genomic ancestries and rates of positive genetic findings in individuals enrolled in a large-scale return of results study for…Parkinson’s disease (PD) associated with the E46K mutation in the SNCA gene, twenty years after
Objective: To provide an updated overview of Parkinson’s disease (PD) associated with E46K mutation carriers in the SNCA gene 20 years after its description, incorporating…Asymptomatic GBA1 Mutation Carriers Have Increased Cortical Cholinergic Activity
Objective: The objective of this study was to assess cholinergic activity changes in patients with Parkinson’s disease carrying GBA1 variants(GBA-PD) and in non-manifesting carriers(GBA-NMC) using…
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