A Systematic Review on the Reliability of Data-Driven Parkinson’s Disease Subtypes
Objective: To systematically evaluate data-driven Parkinson’s disease (PD) subtyping studies, focusing on their methodological quality and clinical applicability. Background: The heterogeneity of PD suggests distinct…Prospective observational study on the effects of physical exercise and lifestyle modifications in patients with Parkinson’s disease
Objective: This study aimed to assess the effectiveness of physical activity, which includes all movements that increase energy expenditure, in conjunction with exercise, characterized as…Noise assessment acoustic measures of sustained vowel in patients with Parkinson’s disease
Objective: To investigate and quantify the presence of noise in the vocal signals of Parkinson's disease (PD) patients and healthy volunteers (HV) using acoustic measures,…Long-Term Benefits of Weekly Group Physiotherapy in Slowing Parkinson’s Progression:A 12-Month Non-Randomized Controlled Trial
Objective: To investigate the effects of weekly group PT programs to reduce the progression of motor symptoms severity in PwPD Background: The short-term benefits of…Caregiver Burden after DBS at GPI or STN for Parkinson’s Disease
Objective: Examine the effects of GPi or STN DBS on caregiver burden for Parkinson's Disease Background: Deep Brain Stimulation (DBS) is a common treatment used…Long term real-world monitoring supports the superiority of adaptive deep brain stimulation: preliminary data on three patients with Parkinson’s disease
Objective: Describe the preliminary results of adaptive deep brain stimulation (aDBS) treatment for Parkinson’s disease (PD) and the value of real-world monitoring in defining clinical…Trends on recruitment and retention in Parkinson’s Disease modification trials
Objective: To identify the most common causes of participant’s screen failure (SF) and drop-out (DO) in Phase 2 and 3 Disease Modification Therapy (DMT) trials…A randomised controlled feasibility study of a technology-assisted home-based aerobic exercise program for individuals with Parkinson’s disease
Objective: The study evaluates the effectiveness of Combat PD, a mobile app designed to remotely deliver and monitor gamified aerobic exercise in promoting adherence and…First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Doses of ARV-102, a PROTAC LRRK2 Degrader, in Healthy Participants
Objective: To evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple ascending doses (SAD/MAD) of ARV-102, a PROteolysis TArgeting Chimera (PROTAC) leucine-rich…Barriers and Facilitators of Adherence to Mediterranean-Ketogenic and MCT-Supplemented Mediterranean Diets in Parkinson’s Disease: A Qualitative Secondary Analysis from a Random-Order Crossover Trial
Objective: To assess the barriers and facilitators of dietary adherence among people with Parkinson’s disease (PD) following an 8-week Mediterranean-ketogenic and 8-week MCT-supplemented Mediterranean diet.…
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