Continued Evaluation of Bemdaneprocel Following a Phase 1 Study for Parkinson’s Disease: Outcomes Through 3 Years
Objective: To report the safety and clinical outcomes of bemdaneprocel in participants with Parkinson’s disease (PD) through 3 years post transplantation. Background: Bemdaneprocel is an…Computer Vision Quantification of Repeated Finger Tapping Demonstrates Aberrant Plasticity in Parkinson’s Disease
Objective: Test if symptoms of Parkinson's disease (PD) develop through aberrant plasticity. Background: Recent results in 6-hydroxydopamine-lesioned mice show that repeated performance of simple motor…Cerebrospinal fluid measured α-synuclein is related to metabolite profile in the serum and CSF
Objective: Determine metabolites associated with cerebrospinal fluid (CSF) measured α-synuclein (α-syn) using untargeted metabolomics measured in the serum and CSF. Background: Several large studies have…Identifying the Prognostic Outcomes of Parkinson’s Patients with Impaired Swallow.
Objective: To identify the prognostic outcomes of patients with Parkinson’s disease (PD) when they are unable to take their oral medication and are medicated via…VQ-101, a CNS-Penetrant Small Molecule Allosteric Activator of Glucocerebrosidase (GCase), Demonstrates Favorable Tolerability and Sustained Activation of Lysosomal GCase in Individuals with Parkinson’s Disease
Objective: To assess the safety, tolerability, pharmacokinetics and pharmacodynamics of VQ-101 in healthy volunteers (HVs), and individuals with Parkinson’s disease (PD) with and without GBA1…Comparing the Impact of Levodopa versus Pramipexole on Eye-Tracking Parameters in Treatment-Naïve Parkinson’s Disease: A Longitudinal Study
Objective: To investigate the differential effects of levodopa versus pramipexole on eye-tracking parameters in treatment-naïve patients with Parkinson's disease. Background: Parkinson's disease (PD) is characterized…Patient And Clinician Perceptions Of Disease Improvement With Levodopa–Entacapone–Carbidopa Intestinal Gel (LECIG) In Advanced Parkinson’s – Data From The ELEGANCE Interim Analysis
Objective: To evaluate clinicians’ and patients’ views of the level of improvement in Parkinson’s disease (PD) achieved following up to two years of treatment with…Efficacy and Safety of Nicotine in Parkinson’s Disease: A Systematic Review and Meta-analysis
Objective: This systematic review and meta-analysis aimed to evaluate the safety and efficacy of nicotine compared with placebo in the treatment of Parkinson’s disease (PD).…Motor Fluctuations in Parkinsons Disease and their Correction
Objective: To evaluate the frequency of motor fluctuations in patients with Parkinson's disease and to study the effectiveness of methods modifying the course of the…Comprehensive Multi-Platform Proteomic Analysis Identifies Novel Biomarkers for Parkinson’s Disease Diagnosis and Progression Monitoring
Objective: To replicate existing and identify novel protein biomarkers for PD diagnosis and progression. Background: Parkinson's disease (PD) lacks reliable biomarkers for early diagnosis and…
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