The Unique Clinical Profile of Dystonia in Parkinson Disease
Objective: Characterize clinical features of dystonia and levodopa-related dyskinesias in Parkinson disease (PD). Background: Dystonia affects 30-60% of individuals with PD. [1] Despite recognition as…Secular trends and survival of Parkinson’s disease and other forms of parkinsonism in the United Kingdom
Objective: We examined the UK incidence, prevalence and survival for eight parkinsonian disorders including Parkinson’s disease (PD) from 2003 to 2023, using primary and secondary…Efficacy of Rifaximin as an Adjunct Treatment for Levodopa induced dyskinesia: Preliminary Results
Objective: To evaluate the efficacy of rifaximin as an adjunct treatment for LID (levodopa induced dyskinesia) in patients with PD through a randomized, double-blind, placebo-controlled…Center of Mass and Center of Pressure interactions during Gait in people with Parkinson’s Disease
Objective: To compare lateral stability during gait in people with Parkinson’s Disease (PD), compared to healthy controls (HC). Background: PD is a progressive neurodegenerative disorder[1],…People With Parkinson’s Disease and Care Partners Experience Costly Work Productivity Loss
Objective: To evaluate work productivity loss (WPL) and associated costs among people with newly diagnosed Parkinson’s Disease (nPD), advanced PD (aPD), and care partners (CP).…Clinical Characteristics of Parkinsons Disease and their Role in Differential Diagnosis
Objective: To study and systematize the clinical characteristics of Parkinson's disease (PD) and their role in differential diagnosis with other parkinsonian syndromes. Background: Parkinson’s disease…GCase and Ganglioside GM1 Interaction in Parkinson’s Disease
Objective: The project aims to further understand the role of the ganglioside GM1 in the relationship between GBA1 mutations and higher α-synuclein levels. Background: Among…Complement C4 Exacerbates Inflammation and Neuronal Damage in Vivo
Objective: To investigate the specific effects of the core complement component C4 on α-synuclein aggregation and neuroinflammation during the pathogenesis of PD. Background: Synucleinopathies are…Longitudinal Brain Morphometric Trajectories Across Parkinson Disease Clinical Subtypes
Objective: To investigate longitudinal brain morphometric trajectories across Parkinson disease (PD) clinical subtypes Background: We developed a PD multi-domain classification based on motor and non-motor…Mathematical and Computational Modeling Prototype to Understand the Evolution of Parkinson’s disease using Four Differential Equations
Objective: Apply four differential equations to generate projections considering the effect of dopamine on Parkinson’s disease progression, leading to the development of an initial prototype…
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