Metabolic-Structural Patterns Across Progressive Supranuclear Palsy Clinical Variants: a Multimodal PET-MRI Study
Objective: To characterize patterns of regional glucose hypometabolism on Fluorodeoxyglucose (FDG)-PET and structural atrophy on MRI across clinical variants of progressive supranuclear palsy (PSP). Background:…Distinct Glymphatic Pathways Underlie Prodromal and Clinical Features of Parkinson’s Disease
Objective: To examine compartment-specific glymphatic alterations across prodromal and clinical stages of Parkinson’s disease (PD) and their associations with clinical features. We hypothesized that PA…Early-Onset Parkinson’s Disease Is Associated With Higher Utilization of Deep Brain Stimulation: Real-World Data From a Tertiary Movement Disorders Clinic
Objective: To characterize the frequency of early-onset Parkinson’s disease and the use of deep brain stimulation among Parkinson’s disease patients evaluated in a tertiary movement…Investigation of Sex-based Differences in the Utility of IgG Index as a Potential Predictor of Cognitive Impairment in Parkinson’s Disease
Objective: Determine if there are sex-based differences in associations of baseline (BL) immunoglobulin G (IgG) index with development of cognitive impairment (CI) among cognitively normal…Subthalamic Beta Sub-band Composition and Gamma Dynamics Across Medication and Stimulation States in Parkinson’s Disease
Objective: To examine how levodopa pharmacodynamics and therapeutic deep brain stimulation (DBS) shape beta sub-band composition and gamma oscillations in the subthalamic nucleus (STN), and…Set_my_DBS: Multicenter study for the development of quantitative methods to support the programming of deep brain stimulation systems in patients with Parkinson’s disease.
Objective: To develop quantitative methods to assist clinicians in the programming of DBS systems, while establishing a consortium-based protocol among participating hospitals andcreating a secure…Novel Modeling Approach for Comparing Treatment-Naive and Post-Treatment Neuronal Synucleinopathy Progression Using Multi-Modal PPMI Data
Objective: To characterize multi-domain progression over the course of Neuronal alpha-Synuclein Disease (NSD), in both treatment-naive and treated individuals. Background: Neuronal alpha-Synuclein Disease (NSD), a…Functional Movement Disorders in a Public Health System: Misdiagnosis, Diagnostic Delay, and Healthcare Utilization in 61 Patients
Objective: To characterize diagnostic delay, patterns of misdiagnosis, and healthcare utilization before diagnosis of FMD in patients evaluated in a tertiary public hospital in Peru.…A Genome-Wide Search for Common Variants Modifying Age at Onset in PRKN-Associated Parkinson’s Disease
Objective: The aim of this study was to identify potential genetic modifiers of age at onset in PRKN-associated Parkinson's disease (PD) through a genome-wide association…Sensor-Derived Gait Patterns Predict Motor Progression in Parkinson’s Disease Beyond Baseline Dopamine Transporter Imaging
Objective: To determine whether baseline sensor-derived gait pattern scores provide superior prognostic value compared with baseline dopamine transporter (DAT) imaging for predicting longitudinal gait deterioration…
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