Receptor Selectivity Profile and Clinical Significance of Ecopipam and Its Metabolites as a Potential Therapy for Tourette Syndrome
Objective: To characterize the binding/inhibition and potential clinical relevance of ecopipam and its metabolites across a wide array of potential off-target receptors, ion channels, enzymes,…12-week Aerobic Interval Training Induces Hemisphere-Specific Neuroprotection in Parkinson’s Disease: A Multimodal MRI, [18F]Fluorodopa PET/CT and BDNF Study
Objective: To investigate whether a 12-week aerobic interval training (AIT) can preserve subcortical brain structures in early Parkinson’s disease (PD) and whether these effects are…Characterizing Local Field Potentials in Early-Onset Dystonia
Objective: To investigate the role of local field potential (LFP) recordings as biomarkers of dystonia severity in patients with pallidal deep brain stimulation (DBS) systems…The Impact of Insurance on Delivery of Huntington’s Care at an HDSA Center of Excellence
Objective: To determine the association between health insurance and Huntington’s Disease (HD) time to diagnosis, delays in access to specialty care, and HD specific clinical…Interventions in Friedreich’s Ataxia and their Influence on Patient-centric Outcomes: A Systematic Review
Objective: The presented systematic review summarizes available pharmacological and non‑pharmacological interventions for patients with Friedreich's ataxia, their outcomes, and alignment with patient‑centered health domains as…Rhythmic circular stump movements after traumatic amputation: jumping stump syndrome with rapid remission after botulinum toxin type A
Objective: To describe the clinical phenomenology and treatment response of post-traumatic jumping stump syndrome following above-knee amputation. Background: Peripherally induced movement disorders are an underrecognized…Beyond the Brain: Resting Tremor as a Presentation of Cervical Spinal Schwannoma
Objective: Tremor is classically attributed to abnormalities within supraspinal motor circuits, most commonly the cerebellum, thalamus, red nucleus or basal ganglia and rarely considered a…Characterising Consent and Engagement with Remote Blood Collection in PREDICT-PD
Objective: To characterise patterns of non-consent to optional biosample donation (Aim 1) and post-consent engagement (Aim 2) with remote blood collection in PREDICT-PD. Background: PREDICT-PD…Effect of Poor Sleep Quality on Fatigue Severity in Parkinson’s Disease
Objective: To investigate the effect of poor sleep quality on fatigue severity Background: Poor sleep quality is observed in 60% of Parkinson's Disease (PD). The…Drivers of Navigated Walking Performance in Aging and Parkinson’s Disease: Insights From Behavioral Clustering, Clinical and Neuroimaging Data
Objective: Identify and characterize patterns of navigated walking performance in people with PD (Parkinson’s disease) and healthy adults, by means of data-driven cluster analysis. Background:…
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