Dorsal STN and Zona Incerta Stimulation as a Strategy to Reduce Dyskinesia after STN-DBS: A Case Series with Literature Reviews
Objective: These case series illustrate practical programming strategies and clinical decision-making in real-world DBS practice using the concept of stimulating the dorsal STN or ZI…Dentatothalamic Projections Mediate Tremor Relief Across Deep Brain Stimulation Targets and Tremor Types
Objective: To investigate the neuroanatomical hotspots for the suppression of rest, postural and intention tremor in Parkinson’s Disease (PD) and Essential Tremor (ET) treated with…Cell-type-specific asynchronous aging acceleration across movement disorders
Objective: To quantify brain cell-type–specific biological aging across different movement disorders (MDS) and compare similarities and differences in cellular aging patterns among MDS. Background: It…Diagnostic Validity of PD Identification in a Neurologist-Certified National Drug Reimbursement Registry
Objective: To evaluate the diagnostic validity of PD identification in a national drug reimbursement registry requiring neurologist-confirmed diagnoses. Background: Administrative healthcare databases are widely used…Switching to IPX203 from IPX066 Significantly Improves “Good On” Time and Reduces Motor Fluctuations Under Real-World Conditions
Objective: To evaluate the change in daily “Good On” time and motor fluctuations during conversion of patients from IPX066 to IPX203 as an interim analysis…Evaluating the Conversion of Immediate-Release and/or Extended-Release Levodopa to IPX203 in Patients with Parkinson’s Disease
Objective: This quality improvement (QI) project was conducted to evaluate the impact of the conversion from immediate-release (IR) and/or extended-release (ER) levodopa (LD) to mucoadhesive polymer…Deciphering the NLRP3-Driven Olfactory–Brain Axis in Parkinson’s disease: Neuroprotective Role of Betulin
Objective: The present study aimed to elucidate the molecular mechanism underlying bidirectional olfactory–brain dysfunction mediated through NLRP3 inflammasome activation in cellular models of PD and…Levodopa dosing regimen influences repetitive tongue force maintenance in Parkinson’s disease
Objective: To investigate whether levodopa (LD) dosing regimen influences the dynamics of repetitive maximal tongue pressure (MTP) in patients with Parkinson’s disease (PD). Background: Reduced…Remaining unmet needs in Essential Tremor and Parkinson’s Disease: European Neurologists’ Assessments of Pharmacologic Response and Advanced Therapy Use
Objective: To investigate neurologists’ perceptions of treatment effectiveness and criteria for selecting patients for advanced therapies in essential tremor (ET) and Parkinson’s disease (PD). Background:…Objective Parkinson’s Diagnosis Using a Novel Accelerometer Assessment and Machine Learning
Objective: To evaluate a novel motor assessment using a handheld accelerometer and machine learning to objectively support Parkinson's disease (PD) diagnosis. Background: PD diagnosis is…
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