Automated Closed-Loop DBS Using AI Decoding in Parkinson’s Disease: A Systematic Review and Meta-Analysis of UPDRS-III Improvements in tremor, bradykinesia and Motor Fluctuations.
Objective: We conducted a systematic review and meta-analysis (SRMA) to evaluate the efficacy of adaptive Deep Brain Stimulation (aDBS) compared to conventional Deep Brain Stimulation…Rehabilitation Following Initiation of Device Assisted Treatment in Parkinson’s Disease – a Randomized Controlled Trial
Objective: To investigate if coordinated rehabilitation after starting Device Assisted Treatment (DAT) improves daily activity performance/skills, participation, and disease specific quality of life. Background: DATs…Multi-omic, Multi-polygenic Score Prediction of Parkinson’s disease
Objective: To integrate polygenic scores (PGS) for blood-based omics (gene expression, protein and metabolite levels) in machine learning models to improve the prediction of Parkinson’s…Cryptococcal Meningitis Presenting with Lower Body Parkinsonism and Generalized Chorea: A Case Report
Objective: To report a case of cryptococcal meningitis in a person living with Human immunodeficiency virus (HIV) presented with lower body parkinsonism and subsequent generalized…Effects of a Six-Week Neurorehabilitation Program on Ataxia, Balance and Gait in a Patient with CANVAS Syndrome: A Case Report
Objective: This study aimed to examine the effects of a neurologic physiotherapy on ataxia, balance, and gait in a patient with cerebellar ataxia, neuropathy, and…“Most of us are improvising with the work we are doing”: Perspectives of health and social care professionals in Ghana and Kenya on mobility management for Parkinson’s disease
Objective: To explore perspectives of health and social care professionals (HSCPs) in Ghana and Kenya on clinical mobility management for Parkinson’s disease (PD). Background: Mobility…Translational evaluation of CSF as a relevant compartment for assessing target engagement of therapeutic anti–α-syn antibodies.
Objective: To evaluate a translational free/total α-synuclein (α-syn) assay framework to quantify in vivo target engagement (TE) of anti–α-syn antibodies in preclinical models and to…A Cumulative Genetic Risk Score Predicts Progression in Parkinson’s Disease: 5-year longitudinal study from The Early Parkinson’s disease Longitudinal Singapore (PALS) cohort
Objective: To assess the impact of genetic burden in Parkinson’s disease (PD) progression over 5 years. Background: Individual genetic variants have been shown to influence longitudinal…Genotype-Specific Risk Factors for Falls in Spinocerebellar Ataxia: A Cross-Sectional Analysis of SCA1, SCA2, SCA3, and SCA6
Objective: To determine fall prevalence and identify predictors of fall risk across SCA1, SCA2, SCA3, and SCA6. Background: Falls represent a major source of morbidity in spinocerebellar…Processing Speed across Huntington’s Disease Stages and its association with Striatal PDE10A Density
Objective: To characterise symbol digit modality test (SDMT) performance and its relationship with striatal phosphodiesterase 10A (PDE10A) binding potential across different Huntington’s Disease (HD) stages…
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