Epigenome-wide and gene-targeted epigenetic profile of isolated REM Sleep Behaviour Disorder: a clinico-molecular study
Objective: Comprehensively characterize the epigenetic profile of isolated REM Sleep Behaviour Disorder (iRBD) using genome-wide and gene-targeted approaches, linking it to clinical measures and phenoconversion.…Role of APOE Polymorphism and CSF Markers of AD Co-Pathology in the Cognitive Trajectories of Sporadic and Genetic Parkinson’s Disease: A Longitudinal Cohort Study
Objective: To evaluate if APOE genotype and CSF biomarkers of AD co-pathology are associated with distinct rates of cognitive decline in PD subtypes. Background: Cognitive…Comparison of clinical symptoms between young-onset and elderly-onset in patient with early Parkinson’s disease
Objective: We compared the clinical symptoms of early Parkinson's disease (PD) between young-onset and elderly-onset. Background: The progression of PD varies depending on the age…Epidemiology of Parkinson’s disease in Southern Brazil: Age- and Sex-Specific Findings from the PROBE-PD Study
Objective: To examine the prevalence of Parkinson’s disease and parkinsonism in individuals aged 60 years and older in a population-based sample from Southern Brazil, analyzing…Planning for the Parkinson’s Pandemic: Care needs in Australian Residential Aged Care Facilities
Objective: To evaluate the prevalence, demographic characteristics and care needs of people with Parkinson’s disease (PD) living permanently in residential aged care facilities (RACF) in…Ecologically Valid, Ambient, Longitudinal, and Unbiased Assessment of Treatment Efficacy in Parkinson’s Disease (EVALUATE-PD)
Objective: To determine the feasibility of using in-home digital biomarkers (DBs) and activity monitoring for clinical trials and studies of early Parkinson’s Disease (PD) and…Impact of Innovative Physiotherapy Interventions on Motor Function and Quality of Life in Patients with Parkinson’s Disease and Movement Disorders
Objective: 1. Assess the extent to which innovative physiotherapy interventions improve motor function, as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS).2. Determine the…Breaking Away From the Ivory Tower
Objective: We describe the evolution of the Geriatric Flying Squad (GFS), a rapid response outreach team for residential aged care facilities (RACFs) in the local…A Long-Living Human Tissue Engineered Nigrostriatal Pathway as a Testbed to Study Parkinson’s Disease
Objective: To create a three dimensional (3D) long-living model of human tissue-engineered nigrostriatal pathway (TE-NSP) comprised of discrete somatic and axonal compartments recapitulating the native…Detection and characterization of rare variants in NOTCH2NLC causing false negative molecular diagnosis through long-read sequencing
Objective: This study investigated a NIID patient with typical clinical and imaging features but no detectable NOTCH2NLC GGC expansion using standard testing. Whole-genome long-read sequencing…
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