Estrogen and progesterone influence membrane functions and glucose transporter expression in synaptosomes of different age groups of naturally menopausal rats
Objective: The objective of this study was to determine the effect of 17 β-estradiol (E2) and progesterone (P4) on the activities of Na+ K+ ATPase, monoamine…Efficacy and safety of safinamide in PD patients over 70 years vs. under 70 years old;
Objective: To search for any differences between efficacy and safety of safinamide in PD patients over 70 years vs. under 70 years old. Background: Safinamide…The prevalence of Parkinson’s disease in a predominantly rural area of North West England
Objective: To calculate the crude and age adjusted prevalence of Parkinson’s disease (PD) in North Cumbria. Background: Prevalence data give insight into disease cause and…Gemini digital twins identified neuro-common and disease-specific drivers of rate of change in NfL in Huntington’s disease, Parkinson disease and Alzheimer disease
Objective: Identify common and disease specific molecular drivers of rate of change in Neurofilament light (NfL) in Huntington’s disease (HD), Parkinson disease (PD) and Alzheimer…Identification of pre-frailty in the elderly through serum metabolomics and its impact on Parkinson’s disease phenotype
Objective: We attempted to better characterize pre-frailty using serum metabolomics in a large cohort of elderly subjects without neurodegenerative diseases. Next, we sought to investigate…Epigenetic clocks suggest accelerated ageing in isolated REM Sleep Behavior Disorder patients
Objective: To investigate biological aging in videopolysomnography (vPSG)-confirmed isolated REM Sleep Behavior Disorder (iRBD) patients and vPSG-negative controls, using DNA methylation-based epigenetic clocks. Background: Isolated…Caregiver burden in Parkinson disease: an updated scoping review
Objective: We performed a scoping review to describe caregiver burden in Parkinson disease (PD) and build on the evidence provided by Mosely at al. [1]…Detection of Camptocormia Using Ultrasound in Parkinson’s Disease
Objective: To investigate whether changes in the lumbar paravertebral muscles (LPM) can be detected using muscle ultrasonography (USG) in patients with Parkinson’s disease (PD, PwP)…Associations between non-motor symptoms and patient characteristics in Parkinson’s disease: A multicenter cross-sectional study
Objective: We aimed to investigate factors associated with non-motor symptoms (NMS) in Parkinson's disease (PD). Background: PD is characterized by a variety of NMS, such…Dopaminergic Neuronal attributes in aging Substantia Nigra and Ventral Tegmental Area of mice strains distinctly sensitive to MPTP
Objective: To determine the age-related changes in neuronal morphology in the substantia nigra pars compacta (SNpc) and Ventral Tegmental Area (VTA) of C57BL/6J and CD-1…
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