Genetic stratification of motor and quality of life outcomes in Parkinson’s disease in the EARLYSTIM study
Objective: We identified (Weiss et al., 2016) that single nucleotide polymorphism (SNPs) of the alpha-synuclein gene (SNCA) predicted the motor effect of subthalamic nucleus stimulation (STN-DBS)…Phosphorylated α-synuclein at serine residue 129 decreased in Parkinson’s disease patients taking 250mg of daily niacin for six months
Objective: The main objective was to determine if α-synuclein could be modulated by niacin supplementation, contributing to improved Parkinson’s disease (PD) symptoms. Background: Niacin supplementation…The role of GBA1 mutations in the relationship between GBA1 and alpha-synuclein in Parkinson disease
Objective: The aim of the study was to understand how the E326K GBA1 mutation results in an increased risk for Parkinson disease, through influencing the…Lack of Toll-like receptor 4 is associated with accumulation of alpha-synuclein in the midbrain Parkinson’s disease mice.
Objective: In this study we aimed to investigate the potential role of Toll-like receptor 4 (TLR4) in mediating both the dopaminergic neuron loss and alpha-synuclein (alpha-SYN)…Oligomeric alpha-synuclein in reflex tears and retinal changes in Parkinson’s disease
Objective: To compare oligomeric alpha-synuclein (α-Syn) in reflex tears and its association with the thickness of retinal layers in Parkinson’s disease (PD) Background: Alpha-synuclein is…Utility of Seed Amplification Assay for Detecting α-synuclein in Formalin-Fixed Paraffin Embedded Skin Samples in Parkinson’s Disease
Objective: To determine the sensitivity for Parkinson’s disease (PD) diagnosis of seed amplification assay (SAA) for α-synuclein (α-syn) in formalin-fixed paraffin-embedded (FFPE) skin specimens and…APEG-PCL Nanoparticles Containing Rifampicin Target Dopaminergic Neurons to reduce α-synuclein aggregation
Objective: There were accumulating evidence proving that rifampicin could protect neurons from apoptosis in Parkinson's disease in-vitro model by regulating SUMO modification of α-synuclein. However,…Autonomic dysfunction and its correlation witn synucleinopathy: an immunohistological study in Tunisian patients with parkinson disease
Objective: Identify autonomic digestive symptoms of Parkinson disease (PD)Identify correlations between autonomic dysfunction and alpha-synuclein immunochemical staining in the upper digestive tract. Background: Pathological processes…Blood microRNA-7 as a Progression Biomarker in Parkinson’s disease
Objective: This study investigates the use of microRNA-7-5p (miR-7-5p) as a potential biomarker for Parkinson’s disease (PD) progression. Background: MiR-7-5 is a microRNA that regulates…Anti-α-synuclein antibody 5G4 differentiates idiopathic REM Sleep Behavior Disorder patients from healthy controls in skin biopsies
Objective: The aim of our study was to assess α-synuclein (α-syn) staining using the 5G4 antibody in skin samples of patients with idiopathic REM Sleep…
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