Case Report of an 82 Year Old Man with an 18 Year History of REM Sleep Behavior Disorder and Colonic Lewy Pathology
Objective: To report a case of an 82-year-old man with a long-standing history of REM sleep behavior disorder (RBD) and colonic Lewy pathology without significant…Analysis of the Association between SNCA Polymorphisms and the Risk of Multiple System Atrophy
Objective: To assess the impact of twenty-one single nucleotide polymorphisms (SNPs) located in different regulatory regions of the SNCA gene on the risk of developing…PADOVA: Topline results from a Phase IIb study of prasinezumab in early-stage Parkinson’s disease participants on stable symptomatic treatment
Objective: To evaluate the effect of prasinezumab on slowing down disease progression in participants with early-stage Parkinson’s disease (PD) on stable symptomatic medication. Background: Prasinezumab…Monitoring Parkinson’s Disease in the Dental Chair
Objective: Our goal is to bridge the mechanistic knowledge gap on the Microbiota-Gut-Oral-Brain-Axis (MGOBA)’s role in Parkinson’s disease (PD) pathogenesis through a case-control, proof-of-concept, observational…Alpha-Synuclein Preformed Fibrils Increase the Frequency of CXCR3+ B-cells in Early-stage Parkinson’s Disease Patients
Objective: To investigate the effect of a-Syn Preformed Fibrils (PFF) on CXCR3 expression on B-cells in Parkinson’s Disease (PD) patients at early (E-PD, diagnosed less…The Impact of Microgravity and Herpes Simplex Virus 1 on Parkinson’s Neurodegeneration and HERV Expression
Objective: The present abstract aims to investigate the impact of viral infections and microgravity exposure in the context of Parkinson’s disease (PD). Background: PD is…Characterization of the Dnajc13 p.N860S mouse model, a physiological model of alpha-Synuclein overexpression
Objective: To characterize the Dnajc13 p.N860S mouse model of familial Parkinson’s disease Background: DNAJC13/RME-8 is a large, multi-domain molecular co-chaperone that facilitates membrane recycling and…Alpha Synuclein Seeding Activity Drives Disease Heterogeneity in an Animal Model of Multiple System Atrophy
Objective: To examine the impact of multiple system atrophy (MSA) brain-derived alpha synuclein (αSyn) with diverse seeding activities in an inoculation-based animal model. Background: We…Assessment of the impact of the diabetic features hyperglycemia and insulin resistance on fibril induced synucleinopathy
Objective: Investigate the effects of diabetic features on the induction and severity of synucleinopathies such as Parkinson’s disease (PD). Background: Type 2 diabetes (T2D) is…Diagnostic accuracy and clinical correlates of real-time quaking-induced conversion assay on gastric biopsy in early Parkinson’s disease
Objective: To evaluate the utility of the real-time quaking-induced conversion (RT-QuIC) assay in stomach biopsies as a biomarker for early Parkinson’s disease (PD) and to…
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