Assessment of α-Synuclein Seeding Activity in the Olfactory Mucosa after SARS-CoV-2: a Pilot Study
Objective: To determine whether symptomatic SARS-CoV-2 infection is associated with local α-synuclein (aSyn) aggregation in the olfactory mucosa (OM) as measured by an aSyn seeding…Proximity Ligation Assay Reveals Early Tractopathy in Parkinson’s Disease
Objective: To determine how α-synuclein (αSyn) pathology extends beyond the neuronal soma in the anterior cingulate cortex (ACC) by mapping early pathological changes within adjacent…GBA1 deficiency promotes tau and TDP-43 co-pathology
Objective: To determine whether mutations in the gene beta-glucocerebrosidase 1 (GBA1), the strongest genetic risk factor for PD, promote tau and TDP-43 co-pathology alongside Lewy…Identification of Alpha-synuclein Pathology in Idiopathic Rapid Eye Movement Sleep Disorder Participants by Seed Amplification Assay
Objective: To assess correlations between cerebrospinal fluid (CSF) α-synuclein seed amplification assay (synSAA) and the phenoconversion rate, timing, and final diagnosis of idiopathic rapid eye…Disrupted Lipid Homeostasis and Mitochondrial Remodeling in A53T α-Synuclein Astrocytes
Objective: This study explores lipid metabolic alterations in human astrocytes carrying the A53T α-synuclein mutation and examines their link to mitochondrial organization and cellular bioenergetics.…Heart Rate Variability as an Independent Predictive Biomarker for Fall Risk in Multiple System Atrophy
Objective: To evaluate the predictive value of short-term heart rate variability (HRV) parameters in assessing recurrent fall risk among patients with Multiple System Atrophy (MSA).…Multi-Modal Profiling of Peripheral and Central Nervous System T Cells Identifies Cytotoxic α-Synuclein-Reactive Immunity in Multiple System Atrophy
Objective: To define α-synuclein-specific peripheral T cell responses in multiple system atrophy (MSA) in comparison with parkinson’s disease (PD) and healthy controls (HC), and to…SAA Positivity Rate Amongst Dual LRRK2-GBA1, GBA1 and LRRK2 Carriers with Parkinson’s Disease
Objective: We investigated positivity rate in dual GBA1+LRRK2-PD by comparing GBA1+LRRK2-PD carriers(n=13), GBA1-PD(n=169) and LRRK2-PD(n=175). Background: GBA1 and LRRK2 variants represent the most common genetic…Aggregation – Dependent Effects of Wild-Type and Mutant α-Synuclein on Synaptic Membrane Fusion
Objective: 1. What is the endogenous form of ⍺-Synuclein in various cell types?2. How do WT ⍺-Synuclein monomer and aggregates affect presynaptic membrane fusion and the…Detection of α-synuclein seeds in skin samples from PPMI participants
Objective: To evaluate the presence of α-synuclein seeds (syn-seeds) in skin samples from PPMI participants, including prodromal, early and late Parkinson’s disease (PD) using a…
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