18F-FD4 PET Reveals α-Synuclein Deposition and Clinical Correlations in Multiple System Atrophy
Objective: This study aimed to determine the potential of 18F-FD4 PET to serve as an in vivo pathology mapping tool for MSA, providing initial proof-of-concept for its use in…smSAA: developing a quantitative seed amplification assay with single molecule spectroscopy
Objective: Alpha-synuclein seed amplification assays (SAA) are highly sensitive and specific for detecting endogenous alpha-synuclein (Syn) seeds and are emerging as diagnostic tools for early…Beyond the Spinal Tap: Diagnostic Accuracy of Alpha-Synuclein Seeding Amplification Assays (SAA) in Cutaneous and Ocular Biofluids – A Comparative Diagnostic Accuracy Review
Objective: To evaluate the diagnostic performance of alpha-synuclein (a-syn) seeding amplification assays (SAA) in skin and tear fluid (TF) as non-invasive alternatives to cerebrospinal fluid…Neuropsychiatric Symptom Evolution Over the First Decade of Biomarker-Defined Parkinson’s Disease
Objective: To examine the evolution of neuropsychiatric symptoms (NPS) in biomarker-defined Parkinson’s disease over the first decade following diagnosis. Background: Parkinson’s disease (PD) is frequently…Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage
Objective: This study explores how non-neuronal dysfunction drives the rapid progression of GBA-PD, aiming to identify therapeutic targets that restore protein degradation and cellular stability.…Longitudinal α-synuclein Seed Amplification Assay Analysis of PPMI Participants
Objective: To evaluate longitudinal consistency in the assessment of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) by α-synuclein seed amplification assay (synSAA). Background: synSAA…Novel Modeling Approach for Comparing Treatment-Naive and Post-Treatment Neuronal Synucleinopathy Progression Using Multi-Modal PPMI Data
Objective: To characterize multi-domain progression over the course of Neuronal alpha-Synuclein Disease (NSD), in both treatment-naive and treated individuals. Background: Neuronal alpha-Synuclein Disease (NSD), a…Urine-derived neuronal extracellular vesicle α-synuclein seed amplification assay for synucleinopathies: a non-invasive biomarker study
Objective: To investigate whether pathogenic α-synuclein can be detected using real-time quaking-induced conversion (RT-QuIC) in urine-derived neuronal extracellular vesicles (NEVs) as a fully non-invasive biomarker…Molecular Profiling of Brain-Derived Extracellular Vesicles and Fluid Biomarkers in Parkinsonism: Distinct Signatures and Clinical Correlates in Progressive Supranuclear Palsy
Objective: (1) To validate serum-based enrichment of neuronal (L1CAM+) and microglial (TMEM119+) EVs in PSP; (2) to characterize α-synuclein, tau, and inflammatory/autophagic mediators in EVs…Seed Amplification Assay Is More Sensitive To Detecting α-Synuclein In Gut Biopsies Than Immunohistochemistry
Objective: Assess seed amplification assay (SAA) and immunohistochemistry (IHC) in peripheral gut mucosal biospecimens as PD diagnostics. Background: SAA detects misfolded alpha-synuclein (α-syn) aggregates across…
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