Fibrinogen and CFAH as putative biomarkers for Parkinson’s disease
Objective: To examine the levels of putative biomarkers FIB, CFAH, gelsolin (GSN), α-syn and phosphorylated-α-syn in PD serum. To localize and quantify FIB and CFAH in…Single-Cell Transcriptomics and Experimental Models Implicate Functional Hypoxia in Microglial DAM Polarization and α-Synuclein Accumulation, with Involvement of HIF-1α, in Parkinson’s Disease
Objective: To investigate whether microcirculatory impairment-induced hypoxia contributes to the emergence of a late-stage disease-associated microglia (DAM) phenotype and impaired α-synuclein clearance in Parkinson's disease…Irisin as a Molecular Mediator of Exercise Induced Neuroprotection and Disease Modification in Parkinson’s Disease
Objective: To integrate mechanistic evidence delineating irisin mediated molecular pathways relevant to Parkinson’s disease (PD) pathogenesis and neuroprotection, focusing on α-syn clearance, autophagy–lysosomal function, mitochondrial…Rare GBA c.1157T>G (p.F386C) Variant in Parkinson’s Disease. Case study.
Objective: To describe the clinical phenotype of a patient with Parkinson's disease who carries a rare heterozygous variant of GBA c.1157T>G (p.F386C) and to analyze…SNCA-Targeting RNAi Therapeutics Prevent Disease Progression in a Synucleinopathy Mouse Model and Enable Robust, Prolonged, and Safe Alpha-Synuclein Protein Reduction in the Cynomolgus Monkey Central Nervous System
Objective: Assess the nonclinical efficacy and safety of C16-conjugated siRNAs targeting SNCA mRNA (SNCA siRNA). Background: Parkinson’s disease is a neurodegenerative disorder with an estimated…Levodopa Responsiveness and Motor Complication Trajectories in Parkinson’s Disease by α-Synuclein Seed Amplification Assay Status
Objective: To investigate whether longitudinal trajectories of medication responsiveness and motor complications differ based on cerebrospinal fluid α-synuclein seed amplification assay (CSF SAA) status in…Dysregulation of lysosomal lipid microdomains impairs autophagic flux in GBA-associated Parkinson’s disease
Objective: To investigate the link between lipid dysregulation and lysosomal dysfunction in GBA-associated Parkinson’s disease (GBA-PD) and explore potential metabolic rescue strategies. Background: Mutations in the GBA gene…A Pilot Study of Phosphorylated Alpha-Synuclein Detection and Quantitation from Routine Colonic Biopsies in Patients with Parkinson’s disease
Objective: To develop a novel method for the detection of P-SYN within superficial colon biopsies that can be obtained during routine colonoscopy. Background: Parkinson’s disease…Diagnosing Prodromal Synucleinopathies – What is the Role of Cardiac MIBG Scintigraphy?
Objective: We aimed to characterize cardiac MIBG uptake patterns in patients with an initial diagnosis of PAF (iPAF) and assess their role as a prognostic…Skin Biopsy for Phosphorylated Alpha-Synuclein and DAT Imaging in Patients Diagnosed with Psychogenic Parkinsonism
Objective: Objective:Describe the results of skin biopsy for phosphorylated alpha-synuclein (P-SYN) and dopamine transporter (DAT) imaging in patients previously diagnosed with psychogenic parkinsonism (PP) and…
- « Previous Page
- 1
- 2
- 3
- 4
- …
- 70
- Next Page »