Unraveling Kinase-Phosphatase Dysregulation in Parkinson’s disease Peripheral Blood Mononuclear Cells Through Targeted Transcript Analysis
Objective: To probe kinase-phosphatase dysregulation and peripheral biomarker potential in peripheral blood mononuclear cells (PBMCs) via LRRK2 (kinase), PPM1H and PP2A (phosphatases), LC3 (autophagy), and…Modulatory effects of bacterial-derived serine protease on pathological α-synuclein fibrillation in vitro
Objective: To investigate the modulatory effects of bacterial-derived proteins on the pathological aggregation of α-synuclein (α-syn) Background: Aggregation of α-syn into toxic oligomers and protofibrils…Beyond the Spinal Tap: Diagnostic Accuracy of Alpha-Synuclein Seeding Amplification Assays (SAA) in Cutaneous and Ocular Biofluids – A Comparative Diagnostic Accuracy Review
Objective: To evaluate the diagnostic performance of alpha-synuclein (a-syn) seeding amplification assays (SAA) in skin and tear fluid (TF) as non-invasive alternatives to cerebrospinal fluid…Neuropsychiatric Symptom Evolution Over the First Decade of Biomarker-Defined Parkinson’s Disease
Objective: To examine the evolution of neuropsychiatric symptoms (NPS) in biomarker-defined Parkinson’s disease over the first decade following diagnosis. Background: Parkinson’s disease (PD) is frequently…Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage
Objective: This study explores how non-neuronal dysfunction drives the rapid progression of GBA-PD, aiming to identify therapeutic targets that restore protein degradation and cellular stability.…Longitudinal α-synuclein Seed Amplification Assay Analysis of PPMI Participants
Objective: To evaluate longitudinal consistency in the assessment of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) by α-synuclein seed amplification assay (synSAA). Background: synSAA…Age-Dependent Peripheral Dissemination of α-Synuclein Seeds: Mechanistic Basis for Blood-Based Early Detection of Parkinson’s Disease
Objective: To evaluate the diagnostic utility of serum α-synuclein (α-Syn) seed amplification assay (SAA) for early PD detection using preformed fibril (PFF)-induced mouse models and…Discordant Siblings Reveal Determinants of Clinical Penetrance in GBA-Associated Parkinson’s Disease
Objective: To investigate clinical, neuropsychological, biomarker, and imaging differences between siblings carrying the same GBA1 variant but discordant for Parkinson’s disease (PD). Background: Variants in…Molecular Profiling of Brain-Derived Extracellular Vesicles and Fluid Biomarkers in Parkinsonism: Distinct Signatures and Clinical Correlates in Progressive Supranuclear Palsy
Objective: (1) To validate serum-based enrichment of neuronal (L1CAM+) and microglial (TMEM119+) EVs in PSP; (2) to characterize α-synuclein, tau, and inflammatory/autophagic mediators in EVs…Seed Amplification Assay Is More Sensitive To Detecting α-Synuclein In Gut Biopsies Than Immunohistochemistry
Objective: Assess seed amplification assay (SAA) and immunohistochemistry (IHC) in peripheral gut mucosal biospecimens as PD diagnostics. Background: SAA detects misfolded alpha-synuclein (α-syn) aggregates across…
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