Relationship Between a-syn RT-QuIC and a-syn Neuropathologic Burden in Dementia with Lewy Bodies
Objective: To determine if measures of alpha-synuclein (a-syn) real time quaking induced conversion (RT-QuIC) activity are related to a-syn neuropathologic burden in dementia with Lewy…Intrastriatal injection of alpha-synuclein preformed fibrils results in cognitive dysfunction and L-DOPA reversible sensorimotor impairments in rats
Objective: To determine the effect of intrastriatal injection of alpha-synuclein (aSyn) preformed fibrils (PFFs) on sensorimotor and non-motor function in rats. Background: The ideal animal…Selective α-synuclein overexpression-induced pathology in noradrenergic neurons: a new mouse model for prodromal Parkinson’s disease?
Objective: To investigate the phenotype of noradrenergic (NA) neurons in an animal model with selective overexpression of α-synuclein (αSyn) in the locus coeruleus (LC) with…Characterization of novel alpha-synuclein aggregation model of Parkinson’s disease
Objective: To establish and characterize a robust alpha-synuclein (aSyn) aggregation pathology research model to allow efficient drug development platform for Parkinson's disease (PD). Background: PD…Unraveling the role of amylin oligomers in synucleinopathies
Objective: The aim of this work is to elucidate the role of amylin in both alpha-synuclein amyloid formation and Parkinson’s disease (PD) and dementia with…The Fragile X Mental Retardation Protein is lost prior to the appearance of Lewy pathology in Parkinson’s disease
Objective: The degeneration of dopaminergic (DA) substantia nigra pars compacta (SNc) neurons is a pathological hallmark of Parkinson's disease (PD). Cell death in PD is…Biomarkers for Parkinson´s Disease with Reflex Tears Correlate with Disease Duration
Objective: To determine if the protein composition of reflex tears differs in Parkinson’s disease (PD) patients stratified by disease duration compared to Healthy Controls (HC).…Identification and characterization of anti-prionic compounds that disassemble αSyn prions as a novel therapeutic approach for synucleinopathies
Objective: Stabilization of monomeric α-synuclein protein (αSyn) by transient and high-affinity binding ligands is a novel and highly innovative anti-prionic treatment strategy for synucleinopathies .…Development and Characterization of an Ultrasensitive Assay Platform for Detection of PD Associated alpha-Synuclein Oligomers in Human Blood
Objective: To develop a sensitive, specific and consistent detection of a-SynO in biofluids to provide a reliable biomarker for disease diagnosis, progression, and a theranostic…miRNA sequencing from routine colonic biopsies reveals an enrichment of submucosal hsa-miRNA-486-5p in Parkinson’s disease
Objective: In the present work, we aimed to investigate the expression of microRNAs (miRNAs) in routine colonic biopsies obtained from patients with idiopathic Parkinson's disease…
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