Association Between Heterozygous Loss-of-Function Variants in the MCOLN1 Gene and α-Synucleinopathies
Objective: To evaluate the association between heterozygous loss-of-function variants in the MCOLN1 gene and α-synucleinopathies. Background: Lysosomes play a crucial role in cellular waste disposal,…Alpha-Synuclein Amplification Assays Utilizing Real-Time Quaking-Induced Conversion (RT-QuIC) from Non-Invasive Saliva as a Novel Diagnostic Tool for Patients with Parkinson’s Disease
Objective: The main objective is to evaluate the sensitivity of aSyn-RT-QuIC in diagnosing Parkinson's Disease (PD) from non-invasive saliva. The results will be corroborated in…The relationship between synuclein-related biomarkers and people with upper-respiratory causes of hyposmia or persistent hyposmia
Objective: To determine how smell-testing can enrich screening for individuals with biomarkers related to neuronal alpha-synucleinopathy-related neurodegeneration (NSD). Background: Loss of sense of smell is the…Mass spectrometry-based screening for α-synuclein bioactive marine natural products
Objective: This study identifies marine-derived natural products with binding affinity and aggregation-inhibition activity against α-synuclein (α-syn) using a mass spectrometry (MS)-based screening approach. The objective…The Impact of Non-Motor Symptoms on Quality of Life in Early Parkinson’s Disease: A Prospective Study
Objective: To assess the prevalence and severity of non-motor symptoms (NMS) in early Parkinson’s disease (PD) and their impact on health-related quality of life (HRQoL).…The A53T mutation in alpha-synuclein impairs astrocytic metabolism and inflammatory response
Objective: This study aims to explore the impact of the A53T alpha-synuclein (α-syn) mutation on astrocytic homeostasis and metabolism in the presence of inflammatory stimuli.…Neutrophil Extracellular Traps Reveal Novel Inflammatory Signatures in Parkinson’s Disease and Multiple System Atrophy
Objective: This cross-sectional study investigates neutrophil extracellular trap (NET) activation in Parkinson’s disease (PD) and multiple system atrophy (MSA) by quantifying plasma levels of NET-associated…Impact of Skin Biopsy Detection of Phosphorylated Alpha-Synuclein and its Distribution Patterns on the Diagnosis of Synucleinopathies
Objective: To assess how skin biopsy detection of phosphorylated alpha-synuclein (P-SYN) and its distribution pattern impact the diagnosis of synucleinopathies, such as Parkinson’s disease (PD),…Lewy Pathology correlates with neuroinflammation in the hippocampus of Synucleinopathy patients in a subregion specific manner
Objective: The objective of this study is to examine the sub-regional differences in neuroinflammation (NI) in response to Lewy pathology (LP) within the hippocampus of…Targeted Brain Delivery of Rifampicin via PEG-PLA Nanoparticles: A Promising Therapeutic Strategy for Neuroprotection and Disease Modification in Parkinsonian Mouse Models
Objective: This study aimed to design and validate a nanoparticle-based delivery system for rifampicin, with the objective of enhancing its therapeutic efficacy, improving brain targeting,…
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