Parkinson’s disease-related non-motor features as risk factors for post-operative delirium in spinal surgery
Objective: We investigated the association between PD-related NMSs and postoperative delirium in old people undergoing elective spinal surgery. Background: The clinical features of postoperative delirium…Skin Deposition of Pathological Alpha-Synuclein in Idiopathic REM-sleep Behavior Disorder and Parkinsonism
Objective: To assess cutaneous pathological Alpha-syn deposition in patients with iRBD, PD, atypical parkinsonism and controls. Background: Peripheral autonomic neurodegeneration may occur in early stages…Tau and α-synuclein autoantibodies as potential biomarkers for Parkinson’s and Alzheimer’s diseases
Objective: To investigate the value of the naturally occurring serum AIAs of α-synuclein (α-syn) and tau, proteins as potential biomarker for diagnosis of PD in…Interaction between PLK2 ( Polo-like kinase-2) and alpha-synuclein in the non-human primate MPTP model of Parkinson disease
Objective: The objective is to determine the levels and interactions between PLK2 and one of its main substrates, synuclein, in the non-human primate MPTP model of…Genetic knock-down of HDAC4 attenuates rotenone-induced abnormal expression of α-synuclein by affecting autophagic flux in SH-SY5Y Cells
Objective: To assess whether histone deacetylase 4 (HDAC4) is related to the abnormal expression of α-synuclein (α-syn) via the autophagy pathway. Background: The overexpression and…Alpha-Synuclein knock-out mouse brain shows significant dysregulation of c-Fos expression
Objective: We aimed to understand the physiological function of alpha-synuclein (SNCA) for neuronal projections within the brain, particularly its effects on entire pathways and on…Epitope mapping of CSF auto-antibodies to alpha-synuclein
Objective: To identify α-synuclein (α-syn) epitopes bound by endogenous auto-antibodies in CSF from healthy controls (HC) and Parkinson disease (PD) patients. Background: In PD, endogenous…Application of a Qualitative Model to Elucidate the Role of the Alpha-Synuclein System in Parkinson’s Disease.
Objective: Objective: In order to improve the understanding of the alpha-synuclein system and its role in Parkinson’s disease, Elan and Rosa collaborated in the development…AAV-mediated human alpha synuclein overexpression in the locus coeruleus (LC) leads to a neuronal loss in the nucleus ambiguus of mouse.
Objective: To investigate the impact and temporal aspects of the neuronal loss in the LC neurons induced by alpha-synucleinopathy Background: In the Braak staging model…The tricyclic antidepressant medication nortriptyline inhibits alpha-synuclein accumulation, aggregation and toxicity in multiple in vitro and in vivo models.
Objective: Using preclinical models, assess the potential disease-modifying effects of nortriptyline (NOR) as a treatment in early Parkinson’s disease (PD). Background: PD and other synucleinopathies…
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