PADOVA: Topline results from a Phase IIb study of prasinezumab in early-stage Parkinson’s disease participants on stable symptomatic treatment
Objective: To evaluate the effect of prasinezumab on slowing down disease progression in participants with early-stage Parkinson’s disease (PD) on stable symptomatic medication. Background: Prasinezumab…Monitoring Parkinson’s Disease in the Dental Chair
Objective: Our goal is to bridge the mechanistic knowledge gap on the Microbiota-Gut-Oral-Brain-Axis (MGOBA)’s role in Parkinson’s disease (PD) pathogenesis through a case-control, proof-of-concept, observational…Alpha-Synuclein Preformed Fibrils Increase the Frequency of CXCR3+ B-cells in Early-stage Parkinson’s Disease Patients
Objective: To investigate the effect of a-Syn Preformed Fibrils (PFF) on CXCR3 expression on B-cells in Parkinson’s Disease (PD) patients at early (E-PD, diagnosed less…The Impact of Microgravity and Herpes Simplex Virus 1 on Parkinson’s Neurodegeneration and HERV Expression
Objective: The present abstract aims to investigate the impact of viral infections and microgravity exposure in the context of Parkinson’s disease (PD). Background: PD is…Characterization of the Dnajc13 p.N860S mouse model, a physiological model of alpha-Synuclein overexpression
Objective: To characterize the Dnajc13 p.N860S mouse model of familial Parkinson’s disease Background: DNAJC13/RME-8 is a large, multi-domain molecular co-chaperone that facilitates membrane recycling and…Clinical Features Suggestive of Alpha-Synucleinopathy in Progressive Supranuclear Palsy
Objective: To compare the presence of symptoms suggestive of synucleinopathy between PSP-parkinsonism (PSP-P), Parkinson's disease (PD) and PSP-Richardson syndrome (PSP-RS). Background: Clinical signs with high…Assessment of the impact of the diabetic features hyperglycemia and insulin resistance on fibril induced synucleinopathy
Objective: Investigate the effects of diabetic features on the induction and severity of synucleinopathies such as Parkinson’s disease (PD). Background: Type 2 diabetes (T2D) is…Diagnostic accuracy and clinical correlates of real-time quaking-induced conversion assay on gastric biopsy in early Parkinson’s disease
Objective: To evaluate the utility of the real-time quaking-induced conversion (RT-QuIC) assay in stomach biopsies as a biomarker for early Parkinson’s disease (PD) and to…Characterization of neuronal exosomes purified from plasma of Parkinson’s Disease Chilean patients
Objective: The diagnosis of PD is usually late and has only palliative treatments that seek to slow the progression of motor symptoms. These characteristics make…Moyamoya Disease and the Risk of Parkinson’s Disease
Objective: We aimed to determine whether the risk of Parkinson’s disease (PD) is increased in patients with Moyamoya disease (MMD) and to identify the potential…
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