String Vessel Formation Regionally Increases in Long Duration Parkinson’s Disease
Objective: Parkinson's disease is a movement disorder characterised by α-synuclein deposition in the form of Lewy bodies and Lewy neurites. Vascular changes have been thought to contribute…Neuroprotective role of baicalein via autophagy mediated modulation of associated motor proteins in experimental animals of Parkinson disease
Objective: To evaluate neuroprotective role of baicalein via autophagy mediated modulation of associated motor proteins in rotenone induced mice model of Parkinson disease. Background: Parkinson's…Bright Light Therapy: A Novel Non-Pharmacological Approach to Parkinson’s Disease
Objective: To assess the effectiveness of Bright Light Therapy (BLT) in ameliorating symptoms and neuropathology in an α-synuclein preformed fibril (α-syn PFF) induced Parkinson’s disease…Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s Disease
Objective: To develop a technology capable of ultra-sensitive, in situ amplification of abnormal conformations of αSyn within biological samples, potentially enhancing diagnostic accuracy and shedding…Alzheimer’s Disease Co-pathology and its Influence on Biofluid Biomarkers in Autopsied Subjects from the PPMI Study
Objective: To examine the relationship between biofluid biomarkers and post-mortem pathological findings in autopsied subjects from the Parkinson’s Progression Marker Initiative (PPMI). Background: The PPMI…Analysis of α-Synuclein Seed Amplification Assay in Carriers of GBA and LRRK2 Pathogenic Variants
Objective: To assess α-synuclein seed amplification assay (αS-SAA) in cerebrospinal fluid (CSF) from a cohort of PD patients and non-manifesting carriers (NMCs) of pathogenic GBA…Synaptic density and α-synuclein oligomers in skin biopsies: differences between idiopathic and GBA-linked Parkinson’s disease
Objective: To compare α-synuclein oligomers and synaptic density (SD) in skin biopsies from PD and GBA-PD. Background: Previous research [1] reported α-synuclein oligomers within synaptic terminals of autonomic fibers in…Cognitive assessment of Parkinson’s disease carriers of the novel p.A30G mutation in the SNCA gene
Objective: The aim of the present report was to evaluate the cognitive profile of symptomatic Parkinson’s disease (PD) patients in a p.A30G SNCA genetic cohort.…The changes in alpha-synuclein level and oscillatory activity of substantia nigra by nigral electrical stimulation
Objective: We aimed to clarify the relationships between the alpha-synuclein level and abnormal oscillatory activity and their changes induced by deep brain stimulation of the…PET visualization of α-synuclein pathologies in humans using [18F]C05-05
Objective: This study aimed to visualize α-synuclein aggregates in living patients with Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).…
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