Impact of Innovative Physiotherapy Interventions on Motor Function and Quality of Life in Patients with Parkinson’s Disease and Movement Disorders
Objective: 1. Assess the extent to which innovative physiotherapy interventions improve motor function, as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS).2. Determine the…Analysis showed resemblance in Genetic architecture of rare movement disorders in consanguineous Pashtoon ethnic group
Objective: Present Study was focused on improving the available genetic architecture of rare movement disorders (MD) and subsequent use of this knowledge for protective measurements…Genotype and age at onset drive vermis atrophy in CACNA1A and GAA-FGF14 related ataxias
Objective: To assess cerebellar volumetry using a deep learning method in patients with non-polyglutamine CACNA1A- or GAA-FGF14-related disease. Background: Ion channel dysfunction is a recurring…Axial Tremor does not correlate with Poor Balance in Essential Tremor
Objective: To explore the correlation between the severity of axial tremor and balance disorder in Essential Tremor (ET). Background: ET is a heterogeneous disorder and…Network localization of limb ataxia
Objective: To identify the neural substrates of limb ataxia caused by stroke lesions. Background: Ataxia is a neurological sign defined by incoordination of voluntary movements.…Pons and middle cerebellar peduncle diameters are diagnostic of Multiple System Atrophy of the Cerebellar Type (MSA-C)
Objective: To develop an MRI biomarker for the definitive diagnosis of Multiple System Atrophy of the Cerebellar Type (MSA-C). Background: MSA is a sporadic, adult-onset…Fragile X Associated Tremor and Ataxia Syndrome (FXTAS) presents with widespread reactive gliosis and white-matter specific astrocyte degeneration
Objective: We will characterize neuropathological alterations of astrocytes in different regions of the FXTAS brain. Background: FXTAS is a progressive neurodegenerative disorder that occurs in…Acute Stimulation-Induced Ataxia From Thalamic Deep Brain Stimulation
Objective: To characterize stimulation-induced ataxia in Essential Tremor patients treated with VIM DBS. Background: In Essential tremor (ET) patients with medically refractory tremor, deep brain…Modeling Cerebellar Limb Dysmetria and Impaired Spatial Memory in Rats Using Lamivudine: A preliminary study
Objective: This study is aimed at determining if any constituent of combination antiretroviral therapy (cART) can induce cerebellar limb dysmetria and spatial memory impairments in…Brain and spinal cord structural alterations in non-ataxic and ataxic SCA3 mutation carriers
Objective: As new therapies for SCA3 are on the horizon, there is an urgent need to identify and validate sensitive biological markers that reflect the…