Modelling spinocerebellar ataxia 15 with iPS cell derived neurons
Objective: Here we set out to study the cellular pathology of ITPR1-deletions underlying SCA15 in a human model of iPSC-derived cortical neurons. Background: Spinocerebellar Ataxia…Deep brain stimulation of the dentate nucleus improves ataxia and modulates cortical excitability
Objective: To assess tremor and ataxia changes by dentate nucleus deep brain stimulation and evaluate how DBS could modulate cortical excitability seen in cerebellar stroke.…Clinical benefits of vestibular rehabilitation in neurodegenerative diseases
Objective: To assess the benefits of vestibular rehabilitation using virtual reality technology through pre and post application of the Dizziness Handicap Inventory (DHI) and the…The nucleocytoplasmic transport of ataxin-3 as pathogenic mechanism in spinocerebellar ataxia type 3
Objective: Spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) is a neurodegenerative disorder caused by a CAG expansion in the MJD1 gene leading to…European pediatric normative values for the scale for assessment and rating of ataxia (SARA)
Objective: To obtain international age-related normative values for the SARA in healthy European children. Background: The Scale for Assessment and Rating of Ataxia (SARA) is…Evaluating the effects of deep brain stimulation (DBS) in mice with spinocerebellar ataxia (SCA1)
Objective: To determine the therapeutic effects of Deep Brain Stimulation (DBS) in mice with Spinocerebellar Ataxia (SCA1). Background: Ataxia is a movement disorder affecting balance…
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