LRRK2 antisense oligonucleotide (BIIB094/ION859) impact on cerebrospinal fluid biomarkers in Parkinson’s disease patients
Objective: To provide novel fluid biomarker results from REASON – a Phase 1 clinical trial testing a LRRK2 antisense oligonucleotide in both LRRK2-Parkinson’s disease and…Differential Motor Cortex Compensation in Parkinson’s Disease based on Putamen Neurodegeneration Laterality: Insights from EEG and [¹⁸F]FDOPA PET/CT
Objective: To investigate differences in motor cortex compensation across Parkinson’s disease (PD) patients with different putamen neurodegeneration laterality. Background: Abnormalities in the putamen–motor cortex (M1)…Organoid-Based AI Clinical Trial Platform for Phase 0 Studies in Parkinson’s Disease
Objective: we developed an organoid-based AI-driven platform to classify patient specific molecular subtypes and predict drug efficacy through an AI-powered validation pipeline. Patient-derived induced pluripotent…Saccadic mask-induced inhibition in Parkinson’s disease
Objective: To investigate the role of the substantia nigra pars reticulata (SNr) in saccadic mask-induced inhibition in Parkinson's disease. Background: Saccadic mask-induced inhibition (SMII) delays…Long-term analysis of subthalamic local field potentials (LFP) in Parkinson’s disease: Insights into circadian rhythms, medication, and personalized treatment effects
Objective: investigate electrophysiological patterns related to circadian rhythms, medication intake & long-term DBS effects. Background: Deep brain stimulation (DBS) offers substantial and long-lasting motor improvements…Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2023: A National Analysis pre and post COVID
Objective: To examine the trends and impact of COVID-19 on Parkinson’s disease (PD) mortality stratified by gender, race and region among older adults in the…Decoding Parkinson’s Progression: Longitudinal Volumetric MRI Biomarkers in Prodromal and Clinical Stages
Objective: This study investigates MRI volumetric analysis via VBM as a biomarker for early PD detection, focusing on structural alterations in deep gray matter regions…Machine Learning Analysis of DTI-Derived Free Water Reveals Distinct Parkinson’s Disease Subtypes: A Two-Year Longitudinal Study
Objective: To identify distinct subtypes of Parkinson’s disease (PD) based on diffusion tensor imaging (DTI)-derived free water (FW) patterns in basal ganglia (BG) structures using…Subthalamic β frequency oscillatory activity is modulated by self-paced wrist movement
Objective: To explore whether subthalamic β oscillatory neurons are associated with the initiation of voluntary movement in patients with Parkinson’s disease (PD). Background: The basal…Post-stroke movement disorders following infarction of the basal ganglia: a pilot study.
Objective: to investigate the clinical features and the occurrence in the long-term follow-up of PMDs in patients with BG lesions due to deep ICH. Background:…
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