Digital Health, Telemedicine, and Artificial Intelligence in Parkinson’s Disease Management During COVID-19: A Narrative Review
Objective: The objective of this narrative review was to evaluate the effectiveness of telemedicine and AI-based technologies used for the remote monitoring and management of…Immune-mediated Chorea in Antiphospholipid Syndrome: Normalization of FDG-PET and Neurofilament as Markers of Treatment Response.
Objective: To present a case where FDG-PET and neurofilament findings help portray the reversibility of neuronal damage in antiphospholipid syndrome (aPL). Background: Chorea is the most common movement disorder in aPL and often an initial manifestation, although…Basal Ganglia Germinoma (BGG) Presenting as Hemidystonia
Objective: We describe an unusual case of progressive right-sided hemidystonia with accompanying imaging and video. Background: Intracranial germinomas most often arise from midline structures, but…Cerebellar-Basal Ganglia Circuitry in the Pathogenesis of Parkinsonian Postural Instability
Objective: To elucidate the role of impaired interactions between the basal ganglia and the cerebellum in the PI development in PD patients. Background: Postural instability…A Novel Homozygous Variant in MYORG is Associated with Primary Brain Calcification and Paroxysmal Dyskinesia
Objective: To report a novel homozygous MYORG mutation causing primary brain calcification (PBC) with paroxysmal dyskinesia and evaluate its functional pathogenicity. Background: PBC is a monogenic…Methanol Intoxication Presenting as a Mixed Ataxic-Parkinsonian Syndrome With a Paradoxical Response to Levodopa: A Case Report
Objective: To report a case of methanol-induced mixed cerebellar and parkinsonian sequelae, emphasizing the pathophysiological mechanisms underlying the neuroimaging findings and the paradoxical response to…Basal Ganglia Pathway Recruitment Determines Bidirectional Bradykinesia Modulation by DBS in Humans
Objective: Understanding the role of distinct basal ganglia pathways in DBS-elicited modulation of bradykinesia across its indications. Background: Opposing bidirectional effects of selective pathway stimulation…Quantitative Assessment of Turning Kinematics and its Association with Parkinson’s Disease Severity
Objective: This study aims to investigate the association between turning performance and disease severity, measured by the MDS-UPDRS and PDQ-39, in people with Parkinson’s disease…Phasic Hemidystonia Secondary to Cavernoma: A Case of Sustained Response to Botulinum Toxin
Objective: To report a rare case of lentiform nucleus cavernoma with phasic-predominant hemidystonia and sustained BoNT response. Background: Cerebral cavernomas rarely present with movement disorders.…Ion Channel Modulation by Dopamine Receptors in Subthalamic Nucleus Neurons: Implications for Parkinson’s Disease Pathophysiology
Objective: Recent neurophysiological studies indicate that dopamine D2 receptors (D2R) may interact with N-type calcium channels in neurons of the subthalamic nucleus (STN), potentially altering…
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