Organoid-Based AI Clinical Trial Platform for Phase 0 Studies in Parkinson’s Disease
Objective: we developed an organoid-based AI-driven platform to classify patient specific molecular subtypes and predict drug efficacy through an AI-powered validation pipeline. Patient-derived induced pluripotent…Saccadic mask-induced inhibition in Parkinson’s disease
Objective: To investigate the role of the substantia nigra pars reticulata (SNr) in saccadic mask-induced inhibition in Parkinson's disease. Background: Saccadic mask-induced inhibition (SMII) delays…Long-term analysis of subthalamic local field potentials (LFP) in Parkinson’s disease: Insights into circadian rhythms, medication, and personalized treatment effects
Objective: investigate electrophysiological patterns related to circadian rhythms, medication intake & long-term DBS effects. Background: Deep brain stimulation (DBS) offers substantial and long-lasting motor improvements…Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2023: A National Analysis pre and post COVID
Objective: To examine the trends and impact of COVID-19 on Parkinson’s disease (PD) mortality stratified by gender, race and region among older adults in the…Decoding Parkinson’s Progression: Longitudinal Volumetric MRI Biomarkers in Prodromal and Clinical Stages
Objective: This study investigates MRI volumetric analysis via VBM as a biomarker for early PD detection, focusing on structural alterations in deep gray matter regions…Machine Learning Analysis of DTI-Derived Free Water Reveals Distinct Parkinson’s Disease Subtypes: A Two-Year Longitudinal Study
Objective: To identify distinct subtypes of Parkinson’s disease (PD) based on diffusion tensor imaging (DTI)-derived free water (FW) patterns in basal ganglia (BG) structures using…Subthalamic β frequency oscillatory activity is modulated by self-paced wrist movement
Objective: To explore whether subthalamic β oscillatory neurons are associated with the initiation of voluntary movement in patients with Parkinson’s disease (PD). Background: The basal…Post-stroke movement disorders following infarction of the basal ganglia: a pilot study.
Objective: to investigate the clinical features and the occurrence in the long-term follow-up of PMDs in patients with BG lesions due to deep ICH. Background:…Exploring pallidal gamma oscillations in Parkinson’s disease: A case report
Objective: To explore the presence and significance of finely tuned gamma in the globus pallidus internus (GPi) in Parkinson's disease (PD). Background: PD is a…Alterations in Basal Ganglia Synaptic Density and Thalamic Gray Matter Volume are associated with Motor Signs in Late Life Depression: an 11C-UCB-J PET/MR study.
Objective: To investigate differences in the association of motor signs with synaptic density, gray matter volume and white matter lesion volume in patients with late…
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