White Matter and Subcortical Alterations in Focal Dystonia: A MRI Study of Subtype-Specific Brain Changes
Objective: To assess structural brain alterations in patients with cervical dystonia (CD) and focal upper limb dystonia (ULD) relative to healthy controls, using MRI exploratory…Preservation of Putamen Volume with Aging in Cervical Dystonia, not other focal dystonia subtypes: A Cross-Sectional Neuroimaging Study
Objective: To investigate whether focal dystonia is associated with altered structural age-related changes in the putamen compared to healthy controls and across dystonia subtypes. Background:…Investigation of cortex – basal ganglia pathways with cortical stimulation and subthalamic evoked responses in patients with Parkinson’s disease
Objective: To investigate the electrophysiological interplay between the human cortex and the subthalamic nucleus (STN) by comparing STN responses to direct cortical electrical stimulation and…LRRK2 antisense oligonucleotide (BIIB094/ION859) impact on cerebrospinal fluid biomarkers in Parkinson’s disease patients
Objective: To provide novel fluid biomarker results from REASON – a Phase 1 clinical trial testing a LRRK2 antisense oligonucleotide in both LRRK2-Parkinson’s disease and…Differential Motor Cortex Compensation in Parkinson’s Disease based on Putamen Neurodegeneration Laterality: Insights from EEG and [¹⁸F]FDOPA PET/CT
Objective: To investigate differences in motor cortex compensation across Parkinson’s disease (PD) patients with different putamen neurodegeneration laterality. Background: Abnormalities in the putamen–motor cortex (M1)…Organoid-Based AI Clinical Trial Platform for Phase 0 Studies in Parkinson’s Disease
Objective: we developed an organoid-based AI-driven platform to classify patient specific molecular subtypes and predict drug efficacy through an AI-powered validation pipeline. Patient-derived induced pluripotent…Saccadic mask-induced inhibition in Parkinson’s disease
Objective: To investigate the role of the substantia nigra pars reticulata (SNr) in saccadic mask-induced inhibition in Parkinson's disease. Background: Saccadic mask-induced inhibition (SMII) delays…Long-term analysis of subthalamic local field potentials (LFP) in Parkinson’s disease: Insights into circadian rhythms, medication, and personalized treatment effects
Objective: investigate electrophysiological patterns related to circadian rhythms, medication intake & long-term DBS effects. Background: Deep brain stimulation (DBS) offers substantial and long-lasting motor improvements…Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2023: A National Analysis pre and post COVID
Objective: To examine the trends and impact of COVID-19 on Parkinson’s disease (PD) mortality stratified by gender, race and region among older adults in the…Dissecting Neural Circuits Regulating Sleep State Transitions in a Mouse Model of Parkinson’s Disease
Objective: To examine sleep architecture in a commonly studied mouse model of Parkinson’s disease (PD) to better understand underlying circuit mechanisms of sleep disturbances in…
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