A double-blind randomized clinical trial to evaluate the effects of Candesartan for Cognitive and Neuropsychiatric Impairment in Parkinson’s Disease
Objective: To explore the feasibility of repurposing candesartan for the treatment of cognitive impairment and neuropsychiatric symptoms in PD. Background: There is an urgent need…Contribution of cognitive load to akinetic and trembling freezing of gait manifestations in patients with Parkinson’s disease
Objective: To evaluate the cognitive contribution of a dual task (DT) or motor plan updating while turning on the akinetic and trembling freezing of gait…Melatonin attenuates the bidirectional Gut-Brain axis mediated inflammation caused by Ambient Particulate Matter (PM2.5) and averts neurodegeneration
Objective: To explore the therapeutic potential of melatonin in attenuating the PM2.5 induced inflammation and neurodegeneration through the Gut-brain axis in C57BL/6 mice. Background: The…Long-Term Neuropsychological Outcomes of Deep Brain Stimulation in Early-Stage Parkinson’s Disease
Objective: To report long-term (5-year and 11-year) neuropsychological outcomes from the deep brain stimulation (DBS) in early-stage Parkinson’s disease (PD) pilot clinical trial. Background: The…Association between longitudinal degeneration of the cholinergic basal forebrain and cognition-relevant cortical areas in early-stage PD
Objective: To examine whether the association between longitudinal cBF degeneration and cognitive decline in PD is mediated by parallel atrophy of cortical areas. Background: Degeneration…Preliminary results on the cognitive profile in prodromal Parkinson’s disease – a prospective study
Objective: This study aims to investigate the cognitive profile in people with REM-sleep behavior disorder (RBD) and hyposmia, in a prodromal Parkinson’s disease (PD) cohort.…ASYMMETRIC EARLY-ONSET PARKINSONISM DUE TO PSEN1 MUTATION
Objective: To report a novel case of early-onset parkinsonism due to a presenilin 1 gene (PSEN1) mutation. Background: Mutations in PSEN1 gene are the most…Non-motor signs in essential tremor and essential tremor-plus syndromes
Objective: To investigate the non-motor profiles of essential tremor (ET) and essential tremor-plus (ET-plus) syndromes. Background: The recently established concept of differentiating ET from ET-plus…Head injury prior to Parkinson’s disease predicts faster self-reported motor and cognitive decline
Objective: To compare rates of self-reported cognitive and motor decline in people with Parkinson’s Disease (PD) with and without a history of head injury (HI).…The Unmet needs for advanced Parkinson Disease in -Patients’ during the Covid-19 pandemic in Israel
Objective: To evaluate the socio-demographic profile and clinical needs of advanced Parkinson's disease patients who were admitted to the neurological department at TASMC during the…
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