Cognitive impairment in early onset and familial Parkinson’s disease.
Objective: The Parkinson’s Families Project (PFP) is a large-scale cohort of early onset (symptom onset <45) and familial Parkinson’s disease (PD) patients. One aim of…Resting state functional connectivity in PD patients with and without Freezing of gait
Objective: To investigate resting state functional connectivity (rsFC) abnormalities in patients with Parkinson's disease (PD), either with (PD-FOG) or without freezing of gait (PD no-FOG). …Speech Markers Estimate Motor Severity and Global Cognition in Parkinson’s Disease
Objective: To utilize free speech characteristics to develop markers of motor and cognitive status in Parkinson’s disease (PD). Background: Vocal biomarkers based on speech volume,…Contact location and non-motor outcomes in subthalamic nucleus deep brain stimulation for Parkinson’s disease
Objective: To determine whether the precise location of stimulation affects cognitive performance and mood. Background: Deep brain stimulation of the subthalamic nucleus effectively treats the…Autosomal Dominant Spinocerebellar Ataxia Secondary to CACNA1G in a Patient of German Ancestry
Objective: We describe the case of a male patient of German ancestry with SCA 42. Background: Hereditary spinocerebellar ataxia (SCA) describes a heterogeneous group of…Validation of a performance-based assessment of functional ability related to cognition in Parkinson’s disease
Objective: Validate the University of California San Diego Performance-Based Skills Assessment (UPSA) in Parkinson's disease (PD) Background: Diagnostic criteria for PD dementia (PDD) require significant…Domain-specific impact of cerebral white matter hyperintensities on Parkinson’s disease cognitive functioning
Objective: In this study, we investigate the relationship between white matter hyperintensities (WMH) and Parkinson's disease (PD) cognitive impairment using a comprehensive neuropsychological battery with…Use of latent class analysis and growth mixture modeling to examine longitudinal neurocognitive trajectories in non-demented Parkinson’s disease
Objective: Examine the utility of latent class analysis (LCA) and growth mixture modeling (GMM) to elucidate cognitive phenotypes and longitudinal trajectories of cognitive change in…Association of the GBA T369M polymorphism with motor and cognitive symptoms in Parkinson’s disease
Objective: To determine whether the GBA polymorphism T369M is associated with earlier age of onset, lower cognitive performance, and more severe motor impairment in Parkinson's…18F-AV-1451 PET imaging in pre-dementia Parkinson’s disease
Objective: To describe cortical and subcortical 18F-AV-1451 binding in Parkinson’s disease patients with and without mild cognitive impairment (PD-MCI and PD-nonMCI). Background: The radioligand 18F-AV-1451…
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