Effect of probiotics on MDS UPDRS in Parkinson disease at 12 weeks: A Randomized double-blind placebo-controlled trial
Objective: The primary objective was to find the effect of 12 weeks of probiotic supplementation on MDS UPDRS score in Parkinson’s Disease. The secondary objectives…Deposition of phosphorylated α-synuclein in the muscularis externa of the gastrointestinal tract in patients with prodromal Parkinson’s disease
Objective: In the present study, we investigated Lewy pathology in the enteric nervous system (ENS) of seven Parkinson’s disease (PD) patients who underwent a gastrectomy,…A study of gut microbiota dynamics in Parkinsonian mice
Objective: To examine gut microbiota in the M83 mouse model of PD. Background: Parkinson’s disease (PD) is a chronic neurodegenerative disease characterized by motor and…Does constipation predict cognitive impairment and dementia in de novo Parkinson’s disease patients? A multi-cohort longitudinal data analysis
Objective: To investigate if constipation predicts the development of cognitive impairment (CI) and dementia in de novo Parkinson’s disease (PD). Background: Constipation is one of…Temporal characterization of motor, gastrointestinal, and behavioral symptoms in a SNCA A53T transgenic mouse model of Parkinson’s disease
Objective: While multiple animal models of Parkinson’s disease (PD) have been developed with varying applicability to different aspects of the disorder, no single model effectively…Association between essential tremor, constipation, and the risk of developing Parkinson’s disease
Objective: To evaluate the association between constipation and the risk of Parkinson’s disease (PD) in patients with a prior history of essential tremor (ET). Background:…Intestinal Methanogen Overgrowth (IMO) More Prevalent than SIBO in Parkinson’s disease with Constipation: Preliminary Results
Objective: Our aim is to quantify the prevalence of small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO) in PD subjects with constipation compared…The Presence of Efferent Brain-Gut Neuropathy Correlates with Severe Constipation in Parkinson’s disease
Objective: We aim to correlate brain-gut neuropathy amongst cortico- and lumbosacro-anorecal efferent pathways in PD subjects with severe constipation measured by prospective stool diary. Background:…Intestinal transit in early-moderate Parkinson’s disease correlates with probable RBD – subclinical esophageal dysmotility does not correlate
Objective: To investigate esophageal and intestinal transit times in early-moderate Parkinson's disease (PD) and to study correlations with probable RBD and subjective symptoms. Background: Intraneuronal…The Gut Dysmotility Questionnaire (GDQ) for Parkinson’s disease: current development
Objective: To develop a questionnaire to screen for and monitor gastrointestinal symptoms in patients with Parkinson’s disease (PD), entitled Gut Dysmotility Questionnaire (GDQ). Background: Gut…
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