Deep brain stimulation in the STN of a Parkinsonian rat model overexpressing human A53T α-synuclein in the substantia nigra – A proof of principle
Objective: To determine if subthalamic nucleus (STN)-deep brain stimulation (DBS) leads to a measurable functional improvement of motor deficits in an AAV1/2 A53T α-synuclein (aSyn)…The effect of short pulse width neurostimulation in GPi-DBS
Objective: To evaluate (1) clinical usefulness and (2) adverse effects of thirty microseconds pulse width stimulation in deep brain stimulation of the globus pallidus internus…Transient, symptomatic, non-infectious hypodensity around deep brain stimulation electrode
Objective: To report a post-operative, transient non-infectious, but symptomatic, brain edema surrounding the deep brain stimulation (DBS) electrode that resolved without intervention. Background: Potential hardware…Tourette syndrome treated by continuous electrical neuromodulation (DBS): Targeting the comorbidities?
Objective: To assess the response to deep brain stimulation (DBS) in refractory Tourette syndrome (rTS) of both tics and behavioural comorbidities. Background: Gilles de la…Phenomenology of dyskinesias induced by subthalamic stimulation in Tourette syndrome
Objective: To describe the phenomenology of dyskinesias induced by subthalamic (STN) stimulation in refractory Tourette syndrome (TS). Background: Dyskinesias occurring following hemorrhagic events in the…Impulse control disorders in Parkinson’s disease – Determinants and effect of DBS
Objective: To assess the frequency and pattern of impulse control disorders (ICDs) and ICD-related behaviours (ICD-RBs) in Indian patients with idiopathic Parkinson's disease and to…Subthalamic nucleus activity during virtual reality provoked lower limb freezing in a patient with Parkinson’s disease and freezing of gait
Objective: Record subthalamic nucleus activity in a Parkinson's disease patient with gait freezing while they perform a virtual reality walking task during DBS surgery. Background:…EARLYSTIM: STN-DBS alleviates behavioural side effects of dopamine replacement therapy when compared to best medical treatment
Objective: To compare effects of STN-DBS and dopamine replacement therapy (DRT) on behaviour in PD in a 2 year follow-up study. Background: A large panel…Subthalamic neurons encode reward hypersensitivity and loss hyposensitivity in Parkinson’s patients with impulse control disorders
Objective: 1) To determine if a subset of subthalamic nucleus (STN) neurons in Parkinson's disease (PD) patients modulate activity in response to valence-related stimuli (reward/punishment)…Long-term effects of pallidal DBS in patients with primary dystonia
Objective: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective treatment for medically refractory dystonia and reduces not only motor impairment…
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