Quantitative assessment of DBS-induced gait disorder in patients with essential tremor
Objective: To investigate changes in gait coordination quantitatively in patients with essential tremor (ET) under chronic bilateral high-frequency stimulation of the nucleus ventralis intermedius (VIM).…Intraoperative localization of beta band and high-frequency oscillations within the subthalamic nucleus
Objective: To investigate whether beta band activity (13-30Hz) and high-frequency oscillations (150-400Hz) arise from the same spatial location within the subthalamic nucleus (STN) of Parkinson's…Combined pallidal and thalamic stimulation for multifocal primary dystonia with prominent writers’ cramp
Objective: When a patient presents with both writer's cramp and other dystonic symptoms, it is unclear which target should be chosen. Multifocal DBS is a…A comparison of deep brain stimulation and continuous intrajejunal levodopa infusion in advanced Parkinson’s disease: The INVEST study
Objective: To compare costs and effectiveness of the therapies DBS and CLI in advanced PD. Background: The therapies deep brain stimulation (DBS) and continuous intrajejunale…Difference between physiologically defined subthalamic nucleus target and final lead placement: Influence in clinical outcome
Objective: To evaluate distance between the physiologically defined subthalamic nucleus (STN) target and final lead placement, and its influence on the clinical outcome at 6…Clinical outcome of subthalamic deep brain stimulation in Parkinson’s disease – The Helsinki experience
Objective: To evaluate the efficacy and adverse effects of subthalamic deep brain stimulation (STN-DBS) in patients with advanced Parkinson's disease (PD) and the possible correlation…Identification of unique metabolite signatures in post-mortem DBS human tissue using LC-HRMS
Objective: Metabolomics is applied to the study of metabolic as well as neurodegenerative diseases. We propose to utilize this technique to detect metabolic changes from…A dopamine-dependent activity of the STN in the control of balance in Parkinson’s disease
Objective: To investigate the activity of the subthalamic nucleus (STN), and its relation to nigro-striatal dopaminergic denervation, in control of balance in Parkinson's disease (PD).…Comparison of clinically derived and model based programming parameters of subthalamic nucleus stimulation in Parkinson’s disease
Objective: To test whether DBS parameters in chronically stimulated Parkinson´s disease (PD) patients chosen by clinical criteria are congruent with DBS parameters as derived from…Variability in the ideal target of GPi DBS for Parkinson’s disease requires advanced direct targeting for optimal results
Objective: Our findings have the potential to transform the clinical practice of surgeons who rely solely on indirect targeting, by raising awareness of the anatomic…
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