transformation of essential tremor into Parkinson’s disease
Objective: To study the percentage of transformation of the diagnosis of essential tremor (ET) into Parkinson's disease (PD) Background: during the initial onset of movement…IParkours : Role of the advanced practice nurse (APN) in the support/follow-up of parkinsonian patients.
Objective: Specify the contribution of APN in the follow up of patient (prescription, follow-up rate, health literacy).Expected evolution to increase the impact of the physician.Fluidify…Can very early levodopa prevent self-injury in Lesch-Nyhan Disease?
Objective: To determine whether levodopa treatment starting at a very young age can prevent the development of the full clinical phenotype in Lesch-Nyhan disease. Background:…Exploring the effects of torsinA dysfunction in an iPSC-derived neuronal model of TOR1A dystonia
Objective: To investigate phenotypic differences between iPSC-differentiated cortical neurons derived from patients with TOR1A dystonia compared to healthy controls. Background: Primary generalised dystonia is most…The Roche ‘End-to-End Matrix’ for Patient-Centric Drug Discovery and Development – Focus on Parkinson’s disease
Objective: To develop an ‘End-to-End Matrix’ for Patient-Centric Drug Discovery and Development to increase the probability of success of clinical trials in Parkinson’s disease. Background:…Comparison of different risk scores for Parkinson’s disease in a population-based 10-year study
Objective: To validate the “enhanced” PREDICT-PD algorithm in a longitudinal population-based cohort and compare its performance with other Parkinson's disease risk scores in identifying cases…Improvement of movement disorder and neurodevelopment under selegiline in a CLTC deficient patient
Objective: We report the significative improvement on both movement disorder and neurodevelopment in a 5-year-old CLTC deficient patient treated with selegiline. Background: In 2019 we described a 30-year-old woman…Impact of the delayed diagnosis in the prognosis of Parkinson’s disease.
Objective: To evaluate the difference of motor and non-motor dysfunction, and quality of life in Parkinson’s disease (PD) patients with and without delayed diagnosis. Background:…A Novel Parkinson Shoe: A potential treatment of Unresponsive Freezing of Gait in Parkinson’s Disease Patients
Objective: To explore the effect of the novel PD shoe on FOG and gait parameters in PD patients with unresponsive FOG. Background: Freezing of gait (FOG) is…Motor Fluctuations development is associated with non-motor symptoms burden progression in Parkinson´s disease patients. A 2-year follow-up study.
Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson´s disease (PD) patients regarding the development…
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