The efficacy and safety of continuous subcutaneous infusion therapy with foslevodopa/foscarbidopa
Objective: To clarify the actual status of CSCI therapy, cases in which CSCI therapy was started at our hospital were investigated. Background: Continuous subcutaneous infusion…A Biomarker-Directed Approach to the Early Diagnosis of Parkinson’s Disease Using Artificial Intelligence and Machine Learning
Objective: The main purpose of this study was to assess how AI and ML methods integrate multiple biomarkers for diagnosing Parkinson’s Disease (PD) to improve…Metabolomic Profiling in an Egyptian Cohort Reveals Altered Phenylalanine Metabolism and Suggests a Role for Trans-Cinnamate in Parkinson Disease
Objective: Investigate the associated metabolic changes in PD via a comprehensive metabolic analysis with a focus on phenylalanine (dopamine precursor) metabolism and its impact on…Profiling Neural Protein Dopaminylation in Parkinson’s disease
Objective: The hallmark of Parkinson’s Disease is motor dysfunction from the decline in dopaminergic cells in the substantia nigra (SN), leading to the development of…Mathematical and Computational Modeling Prototype to Understand the Evolution of Parkinson’s disease using Four Differential Equations
Objective: Apply four differential equations to generate projections considering the effect of dopamine on Parkinson’s disease progression, leading to the development of an initial prototype…Detection and classification of Parkinson’s disease from neuroimaging modalities using machine learning and artificial intelligence: a systematic review
Objective: This systematic review evaluates performance of machine learning (ML) and artificial intelligence (AI) techniques applied to neuroimaging modalities in differentiating Parkinson’s disease (PD) patients…Dopaminometer: A Smartphone-Based Application to Predict Striatal Dopaminergic Deficit in Prodromal and Manifest Parkinson’s disease
Objective: To assess the feasibility of a smartphone-based application (“Dopaminometer”) for predicting abnormal vs. normal dopamine transporter (DaT) scans and dopaminergic ratios in individuals with…Functional Segregation in Parkinson’s Disease
Objective: We assessed patterns of dopamine (DA) release and striatal activation induced by behavioural tasks involving corticostriatal loops in Parkinson’s disease (PD) and healthy control…Artificial Intelligence in the Early Detection of Parkinson’s Disease: Advances, Challenges, and Future Perspectives
Objective: This study reviews AI’s role in early PD detection, comparing AI-driven diagnostic methods with conventional clinical approaches in accuracy, reliability, and applicability. Background: Parkinson’s…The role of serotonergic mechanisms in the formation of levodopa-induced drug-induced dyskinesias in Parkinson’s disease
Objective: To study the quantitative content of serotonin and dopamine in the blood plasma of patients with Parkinson's disease and to conduct a clinical and…
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