Cognitive and depressive behavior changes in aged mice with heterozygous deletions of VMAT2 or of DAT
Objective: To evaluate cognitive and depressive behavior in aged mice with heterozygous deletions of vesicular monoamine transporter (VMAT2) or of Dopamine transporter (DAT). Background: VMAT2…Is the selection of stepping impaired in PD in ON state?
Objective: To compare the selection of stepping actions during a probability reaction time task in people with Parkinson's disease (PD) in the ON state with…Engrailed enhances dopamine synthesis in healthy dopaminergic neurons
Objective: The aim of the present study was to further elucidate the role of Engrailed in dopamine neurotransmission. Background: Engrailed1 and Engrailed2, collectively Engrailed, are…Low cerebrospinal fluid 3,4-dihydroxyphenylacetic acid and 3,4-dihydroxyphenylglycol levels are biomarkers of Parkinsonian disorders, including PSP
Objective: To assess whether Progressive Sopranuclear Palsy (PSP) patients show, in CSF an alteration of catecholamine metabolites. Background: It was reported previously that, consistent with…Apocyanin ameliorates post-stroke movement disorder in rats: Possible role of neurochemical and inflammatory alterations
Objective: To study the neuroprotective efficacy of apocynin, a NADPH oxidase inhibitor in 1) alterations of post- stroke motor behaviour, 2) alterations of various neurotransmitter…Does dopamine affect the selection of stepping actions in PD?
Objective: To compare the selection of stepping actions during a probabilistic reaction time task in the ON state with the OFF state in people with…Computational assessment of calcium channel effects on subthalamic nucleus neuronal cells: Study of abnormal bursting patterns in Parkinson’s disease
Objective: Understanding the drug effects with respect to various ion channels on subthalamic nucleus (STN) cells is the key to safety pharmacology assessment. Here our…The effects of fluvoxamine maleate in a post-natal stress rat model of neurodegeneration
Objective: In this study, we investigated whether treatment of anxiety-like symptoms with Fluvoxamine maleate alleviates the neurotoxic effects of 6-OHDA in a Parkinsonian rat model.…Age associated effects of levodopa administration on striatal acetylcholinesterase activity
Objective: The aim of this study was to compare short- and long-term effects of levodopa on acetylcholinesterase activity in young and old rat brain striatum.…Impact of chronic LD treatment on metabolism, blood flow and blood-brain barrier permeability in the 6-OHDA rat model
Objective: To determine the effects of chronic LD treatment and induction of dyskinesias on cerebral metabolism, blood flow and blood-brain barrier permeability in 6-OHDA rat…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.