Rotenone induces astrocyte-mediated non-cell autonomous dopaminergic neurotoxicity
Objective: In this study, we examined involvement of astrocytes in rotenone-induced dopaminergic neurotoxicity using primary cultured cells. Background: Several studies reported that pesticide exposure, such…Curcumin I prevents the developmental defective sensorimotor patterns resulted from Lead poisoning in rat
Objective: In the present investigation, we evaluated the effect of prenatal exposure of rats to lead from neonatal to adult age on the sensorimotor performances…Patient-derived GBA1-PARK2 double-mutant cellular models to study the effect of GBA1 as a modifier of familial Parkinson’s disease
Objective: In this study, we propose to decipher the role of GBA1 as a modifier of familial Parkinson’s disease (PD) using double-mutant patient-derived cellular models…A neuronal model of PARK20 (SYNJ1 mutation) using patient derived iPSCs
Objective: The SYNJ1 homozygous mutation (p.Arg258Gln) leads to juvenile Parkinsonism (PARK20). SYNJ1 plays an important role in synaptic vesicle cycling, and regulating autophagic flux. We…Neuroprotection of indole-derivative compound NC001-8 in Parkinson disease cell model by regulatory of NRF2 pathway
Objective: The goal of this study is to investigate the effects of indole-derivative compound NC001-8 on neuroprotection in PD disease cell model. Background: Parkinson’s disease…Circadian and Homeostatic Modulation of Multi-unit Activity in Dopaminergic and Striatal Structures
Objective: The aim of this study is to investigate the circadian and homeostatic modulation of the multi-unit activity of dopamineric and striatal neuronal structures. Background:…The Relative Preservation of the Dopaminergic Neuroal Loss of Patients with Parkinson’s Disease Having Dopamine-Unresponsive Resting Tremor
Objective: To investigate the difference of dopaminergic neuronal loss between PD patients with dopamine-unresponsive and -responsive resting tremor. Background: Resting tremor (RT) is one of…Motor dysfunctions in rats following repeated exposure to stress on the neurotoxicity of lambda-cyhalothrin
Objective: To investigate the targets associated in regulating motor functions following subsequent exposure to stress on the neurotoxicity of lambda-cyhalothrin in rats. Background: Stress that…Longitudinal comparison of 11C-PE2I and 18F-DOPA PET for assessing severity and rate of disease progression in patients with Parkinson’s disease
Objective: To directly compare 18F-DOPA with a highly specific dopamine transporter radioligand 11C-PE2I, for the assessment of motor severity and rate of progression in Parkinson's…High-mobility group box 1 from astrocytes upregulates TH expression to maintain dopaminergic neurons via JNK pathway in human Parkinson’s disease patients and MPTP induced mouse model
Objective: Supporting by glial cells could be reinforced the function of dopaminergic neurons against extracellular insults in Parkinson’s disease (PD) development. However, we do not…
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