MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Dopaminergic neurons"

  • 2016 International Congress

    Movement disorders are the common signs as the first neurological deficit in cases with spinocerebellar ataxia type 2 (SCA2)

    N. Miyaue, R. Ando, T. Iwaki, H. Yabe, N. Nishikawa, M. Nagai, H. Takashima, M. Nomoto (Ehime, Toohn City, Japan)

    Objective: We studied neurological signs in cases with SCA2 for early diagnosis. Background: SCA2 is a classification of hereditary ataxia, however, patients with SCA2 have…
  • 2016 International Congress

    Generation and characterization of iPSC-derived nigral dopaminergic and pyramidal glutamatergic neurons from patients affected by multiple system atrophy

    G. Monzio Compagnoni, E. Frattini, S. Salani, F. Fortunato, N. Bresolin, S. Corti, G.P. Comi, A. Di Fonzo (Milan, Italy)

    Objective: The aim of the present study is to generate dopaminergic and pyramidal neurons from iPSCs of MSA patients in order to establish an in…
  • 2016 International Congress

    Diverse effects of alpha-synuclein fibrils on various neuron cell lines, using different buffers

    F. Aliakbari, D. Morshedi, A.A. Shabani, H. Mohammad Beigi, A. Tayaranian Marvian, P. Shariati, S.A. Shojaosadati, A.A. Saboury (Semnan, Islamic Republic of Iran)

    Objective: To investigate the neurotoxic properties of alpha-synuclein (α-Syn) aggregation in different buffers including PBS, SBF and Tris on altered cell lines, SHSY5Y, SK-N-MC and…
  • 2016 International Congress

    Deficiency of HGprt in Lesch-Nyhan disease is associated with abnormal dopaminergic neurodevelopment in vivo

    J.E. Visser, J.S. Witteveen, N.H.M. van Bakel, G.J.M. Martens, S.M. Kolk (Nijmegen, Netherlands)

    Objective: To determine the in vivo effects of hypoxanthine-guanine phosphoribosyl transferase (HGprt) deficiency on dopaminergic neurodevelopment in a genetic mouse model of Lesch-Nyhan disease (LND).…
  • 2016 International Congress

    Functional characterisation and the selective vulnerability of SNCA (A30P) patient-derived midbrain dopaminergic neurons to ER stress

    P.A. Barbuti, B.F.R. Santos, S. Delcambre, Y. Nonnenmacher, C.D. Obermaier, A. Hummel, K. Hiller, R. Krueger (Belvaux, Luxembourg)

    Objective: To functional characterise and phenotype the genetic Parkinson's disease (PD) patient with an A30P point mutation in SNCA using midbrain dopaminergic neurons (mDANs) vs…
  • 2016 International Congress

    Multimodal imaging assessment of nigrostriatal pathway in Parkinson’s disease using 11C-PE2I PET and neuromelanin-sensitive MR

    A. Martin-Bastida, N.P. Lao-Kaim, A.A. Roussakis, W. Li, M. Politis, N. Valle-Guzman, Z. Kefalopoulou, G. Paul, H. Widner, T. Foltynie, R. Barker, P. Piccini (London, United Kingdom)

    Objective: To evaluate the nigrostratal pathway with multimodal assessment using striatal 11C-PE2I PET and nigral Neuromelanin-sensitive MR in Parkinson's disease. Background: The main pathological features…
  • 2016 International Congress

    Characterisation of the A30P mutation in alpha-synuclein gene in patient-derived cellular model of Parkinson’s disease

    B.F.R. Santos, P.A. Barbuti, I. Boussaad, A. Hummel, R. Krüger (Belval, Luxembourg)

    Objective: In this study, we aim to generate and characterise patient-derived midbrain dopaminergic neurons (mDANs) of the A30P Parkinson's disease (PD) familial case. Our goal…
  • 2016 International Congress

    Comparison of DAT and DOPA PET tracer for assessing severity and progression in patients with Parkinson’s disease

    W. Li, N.P. Lao-Kaim, A.A. Roussakis, A. Martin-Bastida, C. Loane, N. Valle-Guzman, Z. Kefalopoulou, M. Politis, T. Foltynie, R.A. Barker, P. Piccini (London, United Kingdom)

    Objective: The aims of this study were to quantify striatal uptake of 18F-DOPA and 11C-PE2I in the same group of PD patients, to assess the…
  • 2016 International Congress

    Pre-formed fibrils injection worsen pathology caused by AAV-mediated over expression of α-synuclein

    L.S. Breger, P. Thakur, O.W. Wan, B. Mattsson, K. Luk, V.M. Lee, J. Trojanowski, A. Björklund (Lund, Sweden)

    Objective: The overall goal is to produce a rat model of Parkinson's disease (PD), which reproduces progressive pathological changes, while displaying profound neuronal cell loss…
  • 2016 International Congress

    Impact of white matter hyperintensity on motor compensation in Parkinson’s disease

    J.J. Lee, Y. Lee, S.J. Chung, P.H. Lee, Y.H. Sohn (Seoul, Korea)

    Objective: To investigate the potential impact of white matter hyperintensity (WMH) on motor compensation in Parkinson's disease (PD). Background: WMHs, the loss of vascular integrity,…
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