Neural correlates of movement sequence kinematics in substantia nigra dopaminergic cells
Objective: To develop a new behavioral task for assessment of mice forelimb movements, and evaluate the substantia nigra pars compacta dopaminergic cells’ (SNpc) correlates of…Admixing augments nigral dopaminergic correlates during development to impart resistance to MPTP-toxicity at adulthood
Objective: Establish the developmental basis for varying nigral dopaminergic (DA) correlates in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) susceptible C57BL/6, MPTP resistant CD-1 and their resistant crossbred mice. Background:…Efficient control of dopamine neuron physiology for rescuing disease phenotypes
Objective: Dopamine neurons (DAs) of the substantia nigra degenerate in Parkinson's disease and are disrupted in Huntington's disease. Here we propose single cell computational modeling…Characterisation of the A30P mutation in alpha-synuclein gene in patient-derived cellular model of Parkinson’s disease
Objective: In this study, we aim to generate and characterise patient-derived midbrain dopaminergic neurons (mDANs) of the A30P Parkinson's disease (PD) familial case. Our goal…Comparison of DAT and DOPA PET tracer for assessing severity and progression in patients with Parkinson’s disease
Objective: The aims of this study were to quantify striatal uptake of 18F-DOPA and 11C-PE2I in the same group of PD patients, to assess the…Pre-formed fibrils injection worsen pathology caused by AAV-mediated over expression of α-synuclein
Objective: The overall goal is to produce a rat model of Parkinson's disease (PD), which reproduces progressive pathological changes, while displaying profound neuronal cell loss…Impact of white matter hyperintensity on motor compensation in Parkinson’s disease
Objective: To investigate the potential impact of white matter hyperintensity (WMH) on motor compensation in Parkinson's disease (PD). Background: WMHs, the loss of vascular integrity,…Presynaptic dopamine depletion predicts late complications and time of progression to advanced disease in patients with early Parkinson’s disease
Objective: To investigate whether the degree of reduced dopamine transporter binding in the striatum is a risk factor for late complications and time of progression…The relationship among clinical features, DAT scintigraphy and MIBG cardiac scintigraphy in patients with Parkinson’s disease
Objective: The aim of this study is to evaluate correlations among clinical features of Parkinson's disease (PD), odor stick identification test for Japanese (OSIT-J) score,…Neuromelanin imaging is useful for monitoring disease progression in Parkinson’s disease and PARK2
Objective: Using neuromelanin (NM)-MRI, we analyzed whether disease severity and MF is associated with the degree of dopaminergic neuronal degeneration in the substantial nigra compacta…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.