Advanced Parkinson’s disease Diagnosis and Treatment Trends in Israel – Sub-Analysis of the OBSERVE-PD Multi-Country, Cross-Sectional Study
Objective: The primary objective of this observational study was to evaluate the proportion of Parkinson’s disease (PD) patients identified as advanced PD (APD) patients according…Determinants of absence of dyskinesia in Parkinson’s disease patients with treatment beyond 10 years
Objective: This study aims to explore the determinants for absence of dyskinesia in patients with Parkinson’s disease (PD) based on a large cohort of Chinese…STN-DBS causing persistent dyskinetic movements in OFF-State
Objective: Transient choreatic movements are known as side effects of DBS of the dorsolateral STN in Parkinson disease (PD). Persistent “brittle” dyskinesia have been reported…Nonlinearities in outcome-specific hazard of motor and nonmotor long-term complications of Parkinson’s disease
Objective: To estimate the specific hazard of motor and nonmotor milestones of Parkinson's disease (PD) progression in the long term. Background: Parkinson’s disease greatly varies…Patients experiencing peak-dose dyskinesia use re-distribution of involuntary movement amplitude throughout their body to minimize the functional impact of dyskinesia
Objective: To investigate the presence of a strategy in dyskinesia amplitude re-distribution enabling patients to perform motor tasks. Background: In Parkinson’s disease (PD), occurrence of…Absence of wearing-off in Parkinson’s disease patients with treatment beyond 10 years
Objective: This study aims to explore the determinants for absence of wearing-off in patients with Parkinson’s disease (PD) based on a large cohort of Chinese…West Sweden Parkinson Objective Measurement Registry Study (WestPORTS)
Objective: To study a population representative Parkinson’s Disease (PD) patient cohort characterized with objective 6x24h home measurements using the Parkinson Kinetigraph (PKG, Global Kinetics). To…Levodopa-induced dyskinesia in Parkinson’s disease: Sleep matters
Objective: To investigate the relationship between slow wave activity (SWA) of non-rapid eye movement (NREM) sleep, which underlies adjustment of cortical excitability, and levodopa-induced dyskinesias…Intrastriatal Fyn silencing as a gene therapy strategy to manage levodopa induced dyskinesia in a mice model of Parkinson’s disease
Objective: To genetically abrogate Fyn expression to reduce levodopa induced dyskinesia (LID) in the 6-OHDA mice model of Parkinson’s disease (PD), using intrastriatal-injected lentiviral (LV)…Combined administration of A2A receptor antagonist and 5-HT1A/1B receptor agonist reverses neuroinflammation in the 6-OHDA model of Parkinson’s disease
Objective: To investigate whether in a model of Parkinson's Disease (PD), an early treatment with the serotonin 5-HT1A/1B receptor agonist eltoprazine and the adenosine A2A…
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