Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism
Objective: We set out to compare patterns of dyskinetic behaviours induced by the systemic administration of L-DOPA and D1 or D2 receptor (D1R, D2R) agonists…Surround inhibition (SI) in the human motor system during real life motor tasks.
Objective: To assess motor SI during real life motor tasks. Background: SI is a neurophysiological mechanism in the human nervous system that focuses neuronal activity…DystoniaNet: Neural Biomarker-Based Platform for Dystonia Diagnosis using Deep Learning
Objective: Development and validation of a deep learning algorithmic platform for the identification of a microstructural biomarker for objective, accurate, and rapid diagnosis of dystonia.…Distinct maladaptive and compensatory wiring patterns in penetrant and non-penetrant dystonia mutation carriers
Objective: DYT1 and DYT6 are autosomal dominant mutations for primary dystonia with incomplete penetrance. We have found that expression levels for a distinct dystonia-related functional…The Impact of the Sensory Trick on Gating Multimodal Afferents in Cervical Dystonia
Objective: To investigate how ST modulate the postural sway in patients with idiopathic cervical dystonia (iCD) when proprioceptive and vestibular stimulation are provided simultaneously. Background: We…Striatal neurodegeneration in the presymptomatic phase of X-linked Dystonia-Parkinsonism
Objective: To identify structural brain changes in patients with X-linked dystonia-parkinsonism (XDP) and non-manifesting carriers of the TAF1 SVA retrotransposon insertion (NMC). Background: XDP is…Fractal analysis of muscle ultrasound imaging to evaluate muscle health and spasticity
Objective: The aim was to assess the capabilities of using fractal analysis of neuromuscular ultrasound images to evaluate muscle health and spasticity. Background: Ultrasound (US)…Characterization of pallidal neuronal activity in X-linked dystonia-parkinsonism – a model disease for compartment degeneration in the striatum
Objective: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a highly effective symptomatic therapy for dystonia in X-linked dystonia-parkinsonism (XDP). A deeper…Writer’s Cramp Dystonia during increasingly complex motor task: analysis of behavior and task fMRI
Objective: To evaluate the relationship between clinical features of dystonia and striatal BOLD activity. Background: Dystonia is a brain disorder which causes involuntary twisting movements, abnormal…A novel phasic and restricted basal ganglia thalamocortical subcircuitry model
Objective: To advance a novel basal ganglia thalamocortical (BGTC) model that accounts for GPi as a tonic-burst mode regulator of the thalamus and for restricted…
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