Suvecaltamide Metabolites Are CaV3 Modulators and Contribute to Pharmacological Effect
Objective: To determine the potency-concentration relationships and combined pharmacological effects for suvecaltamide and its 2 active metabolites (JZZ05000034=M01, JZZ05000035=M02; total active moiety [TAM]). Background: T-type…Classification of Tremor and Myoclonus: An Explainable Machine Learning Approach
Objective: Providing a proof of concept for the classification of movement disorders using explainable machine learning applied to power spectra derived from accelerometry recordings. Background:…Increasing access to Deep Brain Stimulation for an underserved patient population: A retrospective cohort from an urban hospital in a diverse county in the USA.
Objective: To understand whether the presence of a Bilingual Movement Disorder specialist increases access to Deep Brain Stimulation (DBS) for an underserved patient population. Background:…Impact on quality of life and nonmotor symptoms of unilateral magnetic resonance-guided focused ultrasounds (FUS) thalamotomy in patients with essential tremor.
Objective: To describe the impact on quality of life (QoL) and nonmotor symptoms of unilateral magnetic resonance-guided focused ultrasounds (FUS) thalamotomy in patients with refractory…Contribution to Efficacy by Active Metabolites of Suvecaltamide in a Preclinical Rat Model of Essential Tremor
Objective: Present the pharmacokinetic/pharmacodynamic (PK/PD) relationship and contribution to anti-tremor efficacy for suvecaltamide and its active metabolites (JZZ05000034=M01, JZZ05000035=M02) in a harmaline-induced rat model of…Age of Onset and Choice of First-line Therapy in Essential Tremor Patients
Objective: The purpose of this study is to examine the effect of age of onset on the selection of initial medication for symptomatic management of…Anosognosia for hardware-related complications in deep brain stimulation
Objective: In this series, we report two rare cases of selective unawareness to hardware-related complications in deep brain stimulation (DBS). Background: DBS has shown good…Safety and efficacy of bilateral magnetic resonance-guided focused ultrasounds (FUS) thalamotomy for refractory essential tremor.
Objective: To describe the safety and efficacy of bilateral focused ultrasound thalamotomy (FUS) in a cohort of patients with essential tremor (ET) within the Spanish…How Common is Essential Tremor in Germany? A Real-World Claims Data Analysis
Objective: To estimate the prevalence and incidence of essential tremor (ET) stratified by age and sex, using insurance claims data from a large representative [1,2]…Characteristics and Treatment Patterns of Patients Newly Diagnosed With Essential Tremor: A Retrospective Claims Database Analysis in the US
Objective: To understand patient characteristics and real-world medication patterns of patients with essential tremor (ET) being initiated on treatment in the US. Background: ET is…
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