Resting-state functional network alterations in early Parkinson’s disease anxiety: a 7T MRI study
Objective: To investigate alterations in functional connectivity (FC) within and between key resting-state networks in early Parkinson’s disease patients with anxiety, using 7-Tesla (7T) MRI.…Distinct Local and Global Functional Network Reorganization Underlying STN versus GPi DBS in Parkinson’s Disease
Objective: To identify target-specific neuroimaging biomarkers for STN and GPi DBS and evaluate their impact on the global functional hierarchy and clinical outcomes. Background: Selection…Cholinergic dysfunction associated to aberrant functional connectivity in Parkinson Disease-related dystonia
Objective: Assess presynaptic cholinergic integrity and associated functional connectivity differences in Parkinson disease (PD)-related dystonia. Background: Dystonia is observed in 30-60% of individuals with PD.…From Clinical Patterns to Symptom-specific Functional Networks in Dyskinetic Cerebral Palsy
Objective: Investigate clinical motor patterns and evaluate symptom-specific functional motor networks in dyskinetic cerebral palsy. Background: Dyskinetic cerebral palsy (DCP) is a complex movement disorder…Patient-Derived α-Synuclein Kinetic Subtypes Drive Distinct Pathological Propagation Patterns and Brain Network Alterations in Parkinson’s Disease Mouse Models
Objective: To validate whether patient-derived α-synuclein (α-Syn) aggregates with distinct kinetic properties produce differentiated pathological propagation patterns, brain network functional alterations, and behavioral phenotypes in…Default Mode Network Co-Activation Pattern Dynamics and Their Relationship to Cognition in Parkinson’s Disease with and without Mild Cognitive Impairment
Objective: While brain imaging studies have shown disruptions in the default mode network (DMN) related to cognitive difficulties in PD (Wolters et al., 2019; Díez-Cirarda…Resting-state pupil fluctuations reflect monoaminergic brainstem dysfunction associated with non-motor symptoms in early Parkinson’s disease
Objective: To determine whether resting-state pupil fluctuations reflect structural and functional impairment of monoaminergic brainstem nuclei and are associated with non-motor symptom burden in early…Baseline MRI Predictors of Phenoconversion and Prodromal Progression in Non-Manifesting PD Mutation Carriers: A Longitudinal Retrospective Analysis
Objective: We evaluated the sensitivity of baseline MRI measures to predict future PD conversion, and whether baseline MRI associates with MDS prodromal likelihood ratio (LR)…Cerebellar cholinergic denervation relates to impaired gait and cerebellocortical resting-state functional connectivity in Parkinson disease
Objective: The purpose of this cross-sectional study was to investigate the cholinergic denervation of the cerebellum and its contribution to impaired gait and cerebellocortical resting-state…Neural Mechanisms of Motor Dysfunction in Idiopathic REM Sleep Behavior Disorder: An rs-fMRI Study Based on the Purdue Pegboard Test
Objective: This study aimed to investigate the neural mechanisms of motor alterations in idiopathic REM sleep behavior disorder (iRBD) and to determine whether abnormalities in…
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