The Dual Functional Organization of the Substantia Nigra in Parkinson’s Disease
Objective: We applied connectopic mapping to the internal functional organisation of the substantia nigra (SN) in independent cohorts. Background: The human SN is a central…Disease Endophenotyping through Graph and Adjacency Metrics (DEGAS): Network Biomarkers for Parkinson’s Disease Prognosis
Objective: To develop a machine learning framework using resting-state functional connectivity to identify neural signatures of Parkinson's disease (PD) and forecast disease progression. Background: PD…Altered Motor Regulation and Limbic-Motor Circuits in Paroxysmal Kinesigenic Dyskinesia
Objective: To explore underlying circuit-level mechanisms in paroxysmal kinesigenic dyskinesia (PKD). Background: While the cortico-striato-thalamo-cortical loop and cerebellum are implicated in PKD pathophysiology, the causal…Therapeutic effects of intermittent theta-burst stimulation on motor, non-motor symptoms and functional connectivity in de novo Parkinson’s disease
Objective: To evaluate the clinical and resting-state functional connectivity effects of bilateral M1-iTBS in patients with de novo Parkinson’s disease. Background: Dopaminergic neurodegeneration in Parkinson’s…Multilevel Structure-Function Coupling Reveals Network Signatures of Remission in Paroxysmal Kinesigenic Dyskinesia
Objective: To provide a novel neurobiological framework for understanding and predicting clinical trajectories in PKD. Background: Paroxysmal kinesigenic dyskinesia (PKD) causes brief, movement-triggered dystonic or…Functional Connectivity Subtypes Predict Longitudinal Motor Progression and Gait Disturbance in Parkinson’s Disease
Objective: In this study, we aimed to identify network-defined subtypes of Parkinson’s Disease (PD) using resting-state functional connectivity (FC) features and to determine whether these…Altered local synchronization and functional connectivity in Patients with Parkinson’s Disease
Objective: This study aimed to identify the alterations of local synchronization and functional connectivity in PD and explore the acute neural response to acupuncture stimulation…Progressive Dynamic Functional Network Disorganisation and its Association with Phenoconversion in Isolated REM Sleep Behaviour Disorder: A Multicentre Study
Objective: To characterise static and dynamic functional connectivity signatures of disease progression and phenoconversion in a multicentre longitudinal cohort of individuals with isolated REM sleep…Altered Degree Centrality and Its Association with Neurotransmitter Systems in Parkinson’s Disease Patients with Impulse Control Disorders: A Resting-State fMRI Study
Objective: To characterize alterations in local brain function measured by degree centrality (DC) and to explore potential neurotransmitter information in PD patients with ICD (PD-ICD),…Objective Characteristics and Brain Network Alterations in Early-Stage Parkinson’s Disease with Gastric Motility Disorder
Objective: To characterize objective gastric motility disorder (GMD) in early-stage Parkinson’s disease (PD) and explore the underlying central neural network and structural alterations using multimodal…
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