Randomness and bursting of pallidal spiking activity correlates with DBS outcome in Parkinson’s disease and dystonia
Objective: The aim of the current study is to characterize spontaneous pallidal neuronal activity in patients with Pakninson’s disease (PD) and dystonia with different clinical…Tracking Physiological Biomarker Activity in the Globus Pallidus Internus in Two Dystonia Patients Implanted with Medtronic Percept™
Objective: Explore potential biomarkers in dystonia patients implanted with Medtronic Percept™. Background: Though highly variable in presentation and underlying cause, individuals with dystonia present with…Clinical Improvement after Deep Brain Stimulation is associated with the Suppression of Pallidal low-frequency Oscillations in Patients with Dystonia
Objective: to investigate the relationship between pallidal activity and clinical response to deep brain stimulation (DBS) of the globus pallidus internus (GPi) Background: GPi-DBS is…Status Dystonicus is a Distinct State Characterized by Pallidal Beta-band Activity
Objective: To identify distinct pallidal local field potential (LFP) signatures characterizing status dystonicus (SD) from non-SD dystonia. Background: SD is a poorly understood neurological emergency…Direct Targeting Technique of The Globus Pallidus Interna in Primary Dystonia: An Analysis of The Clinical Results And Localization of DBS Electrodes
Objective: The clinical impact of direct globus pallidus internus (GPi) targeting and electrode localization in patients with primary dystonia is investigated. Specifically, it aims to…Low-frequency pallidum evoked potential dynamics as a prospective biomarker for Parkinson’s disease
Objective: Characterize low-frequency evoked potential (EP) activity induced by deep brain stimulation (DBS) in the internal globus pallidus (GPi) and how the EP dynamics modulate…Synchronized High Frequency Neural Oscillations as a Biomarker for Differentiating the Internal from the External Segment of the Globus Pallidus in Parkinson’s Disease
Objective: To assess whether using high frequency oscillations (HFO; 150-350 Hz) or beta band oscillations (13-30 Hz) can objectively differentiate the external from the internal…Dynamics Of Pallidal Beta Activity During Voluntary Movement In Parkinson’s Disease And Cervical Dystonia
Objective: The aim of the current study was to analyze local field potentials (LFP) recorded from globus pallidus (GP) during voluntary movements in patients with…Parameterization of Intraoperative Human Microelectrode Recordings: Linking Action Potential Morphology to Brain Anatomy
Objective: To investigate whether single-unit spike morphology from intraoperative microelectrode recordings (MER) can provide anatomical and physiological insights relevant to deep brain stimulation (DBS) targeting.…Comparison of subthalamic nucleus and globus pallidus internus as deep brain stimulation targets for freezing of gait in Parkinson’s disease
Objective: To compare the short-term effects of deep brain stimulation (DBS) in subthalamic nucleus (STN) and globus pallidus internus (GPi) on freezing of gait (FOG)…
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