Bilateral GPi Deep Brain Stimulation for Severe Speech-Induced Dystonic Dysfluency: A Novel Phenotype at the Stuttering-Dystonia Interface
Objective: To report the first case of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) producing transformative improvement in severe speech-induced dystonic dysfluency at…Monopolar Sensing within the Globus Pallidus and the Relationship between Clinical Outcomes and Anatomy
Objective: This study aims to understand how results from monopolar sensing of local field potential (LFP) beta power can better support more efficient programming of…Anatomical and electrical field determinants of axial motor outcome after bilateral GPi-DBS in Parkinson’s disease
Objective: To determine anatomical and electrical field parameters associated with short-term improvement in axial motor scores after bilateral GPi-DBS in PD. Background: Axial symptoms in…Determinants of Tremor Control Across Severity Levels Following GPi-Deep Brain Stimulation in Parkinson’s Disease
Objective: To compare clinical, stimulation-related, and anatomical determinants of tremor outcome after GPi DBS, between PD patients with severe and mild-moderate tremor. Background: Parkinson’s disease…Automatic Segmentation of the Subthalamic Nucleus and Globus Pallidus Internus: Can it support planning and programming in Deep brain stimulation
Objective: Whether auto-segmentation matches anatomy?Whether auto-segmentation volume difference in either side matches UPDRS score difference between two sides?whether auto-segmentation volume depends on MRI sequence?Whether auto-segmentation…Modulation of Finely Tuned Gamma in the Globus Pallidus Internus with Deep Brain Stimulation and Levodopa
Objective: To characterize narrow band gamma and finely tuned gamma (FTG) in the globus pallidus internus (GPi) in patients with Parkinson’s disease (PD) and the…Portosystemic Shunt Related Parkinsonism in Acquired Hepatocerebral Degeneration With Persistent Pallidal T1 Hyperintensity
Objective: To highlight acquired hepatocerebral degeneration as an underrecognized cause of secondary parkinsonism and to emphasize the diagnostic value of serial MRI in movement disorder…A Specific Neuronal Subpopulation in Globus Pallidus External Segment Mediates the Pathogenesis of Dyskinesia in Parkinson’s Disease
Objective: To clarify the causality between neuronal activity in globus pallidus external segment (GPe) and levodopa-induced dyskinesia (LID), and further ascertain the specificity of this…Stimulation-Level Sweet-Spot and Connectivity Analysis of Pallidal DBS in Huntington’s Disease
Objective: To assess clinical outcomes and identify stimulation and structural connectivity patterns associated with motor improvement in Huntington’s Disease (HD) patients undergoing DBS. Background: DBS…Dual-Node Neuromodulation of the Basal Ganglia Motor Circuit: Sequential STN–GPi Stimulation in Advanced Parkinson’s Disease
Objective: To describe the clinical outcomes of sequential STN–GPi neuromodulation in patients with advanced Parkinson’s disease who developed refractory dyskinesia or dystonia after an initially…
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