Investigating inflammatory mechanisms in iPSC-derived LRRK2 microglia
Objective: To characterize microglial function and inflammatory mechanisms in LRRK2-associated Parkinson’s disease (PD). Background: PD is a neurodegenerative disease affecting primarily dopaminergic neurons of the…Therapeutic potential of luteolin in manganese induced Parkinson’s disease: Targeting neuroinflammation and oxidative stress.
Objective: To investigate the neurodegenerative facets of Manganese (Mn) in rat model in rat model of Parkinson's disease.To study the neuroprotective effect of luteolin in…Molecular alterations and pathological remodeling of colonic wall in patients with Parkinson’s disease
Objective: To evaluate, in an integrated manner, changes in faecal microbiota composition, morpho-functional alterations of the colonic mucosal barrier and changes of inflammatory markers in…Aerobic glycolysis regulates microglia-mediated neuroinflammation by promoting H3K9 lactylation in Parkinson’s disease
Objective: This study aims to investigate the role of histone lactylation in microglia-mediated neuroinflammation and dopaminergic (DA) neuronal damage in Parkinson’s disease (PD). Background: Augmented glycolysis induced by metabolic…Single-cell characterization of patient midbrain tissue reveals tissue remodeling and glial activation in Parkinson’s disease
Objective: We aim to characterize the contribution of each midbrain cell type to PD pathology, and to identify cell types associated with genetic PD-risk variants.…Alteration of peripheral blood cell profiles in Parkinson’s disease: a retrospective case-control study
Objective: The aim of this study is to investigate the relationship between peripheral blood cell profiles and Parkinson's disease (PD). Background: Abnormal immune response and systemic inflammation have…Impact of Th17 pathway-related immuno-inflammatory cytokines in the risk and severity of Parkinson’s Disease.
Objective: To delineate the impact of T helper 17 (Th17) pathway-related cytokines in the risk, severity and psychopathology of patients with Parkinson’s Disease (PD). Background:…mGlu3 receptors in Parkinson’s disease as a candidate target for neuroprotective therapy: evidence from preclinical studies to human genetic.
Objective: In a toxicological model of mouse parkinsonism through chronic injection of MPTP, we examined whether the presence or absence of mGlu3 receptors affected neurodegeneration…Parkin deficiency impairs mtDNA dynamics and propagates inflammation
Objective: We sought to explore Parkin’s role in (i) averting neuronal mtDNA dyshomeostasis/release and (ii) the activation of downstream inflammatory processes. Background: Mutations in Parkin…Increased Prevalence of Thyroid Disease in Cervical Dystonia
Objective: This study evaluated the hypothesis that autoimmune disorders may be more common in cervical dystonia (CD) than neurological controls. Background: Although there are many…
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