CSF inflammatory cytokines and correlation with clinical features in early, untreated PD patients
Objective: The aims of the present study were to investigate the levels of inflammatory cytokines in the cerebrospinal fluid (CSF) of drug-naïve Parkinson's Disease (PD)…Disease progression characterized by motor performance, dopaminergic neurodegeneration and T cell infiltration in the transgenic hm2-α-SYN-39 mouse model of Parkinson´s disease
Objective: To study disease progression in the transgenic (tg) hm2-α-SYN-39 mouse model of Parkinson´s disease (PD) by assessment of motor performance, dopaminergic neurodegeneration and T…A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AKST4290 in Subjects with Parkinson’s Disease on Stable Dopaminergic Treatment (TEAL Study)
Objective: Assessment of efficacy and safety in subjects with Parkinson’s disease (PD) following treatment for 12 weeks with placebo or AKST4290, a highly specific and…Allogeneic bone marrow-derived mesenchymal stem cells safety and tolerability in idiopathic Parkinson’s disease
Objective: Prove safety and feasibility of delivering allogeneic bone marrow-derived mesenchymal stem cells (MSC) intravenously in escalated doses to patients with idiopathic Parkinson’s disease (PD).…Development and validation of a profile of peripheral immune biomarkers for Parkinson’s disease: A multicenter, retrospective study
Objective: This multicenter study was designed to investigate the association between multiple peripheral immune biomarkers and the risk of Parkinson’s disease (PD). Background: Several studies…Predicting the effects of Tumor Necrosis Factor inhibition on the risk and age at onset of Parkinson’s disease: A Mendelian randomization study
Objective: To evaluate whether inhibition of Tumor Necrosis Factor (TNF) signaling may reduce the risk of Parkinson’s disease (PD) and/or delay onset of PD. Background:…Neuroinflammation and Myelin changes in MSA-P evaluated using Advanced Diffusion MRI and Myelin Sensitive Imaging Techniques
Objective: To determine more specific neuropathologies of the white matter in patients with multiple system atrophy-parkinsonian variant (MSA-P) using multi-shell diffusion magnetic resonance imaging (MRI)…Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson’s disease patients with type 2 diabetes mellitus
Objective: Identifying the risk factors of dementia in patients with both Parkinson’s disease (PD) and type 2 diabetes mellitus (DM) (PD-DM) is clinically relevant and…Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease
Objective: Given the presence and function of SRY in male DA (dopamine) neurons, we hypothesised that dysregulation of SRY may contribute to male susceptibility to…Association of Interleukin (IL)-2 and IL2RA gene polymorphisms with Parkinson’s disease in Taiwan
Objective: The purpose of this study is to investigate if interleukin 2 (IL-2) and interleukin 2 receptor alpha (IL2RA) genes are associated with Parkinson’s disease…
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