Inflammatory profile discriminates clinical subtypes in LRRK2-associated PD
Objective: To evaluate whether inflammatory processes in PD patients with mutations in the LRRK2 gene (PD-LRRK2) are associated with modification of clinical features and disease…The movement disorder associated with NMDAR-antibody encephalitis: An expert-rater video study
Objective: To use movement disorder (MD) expert analysis of phenomenology to provide a comprehensive evaluation of the MD associated with NMDA receptor-antibody encephalitis (NMDAR-AbE). Background:…The role of non-steroidal anti-inflammatory use in symptomatic and asymptomatic LRRK2 G2019S mutation carriers
Objective: The purpose of the current study is to determine if non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of Parkinson's disease (PD) among LRRK2 G2019S…The role of neuroinflammation in the development of Parkinson’s disease dementia
Objective: To evaluate, at post-mortem, the pattern and characteristics of neuroinflammatory change in Parkinson's disease (PD) brain and to assess its relationship with aberrant alpha-synuclein,…IL-6 and motor symptoms in Parkinson’s disease
Objective: To assess the concentration of interleukin-6 (IL-6) in serum of patients with PD and its relation to motor symptoms. Background: Participation of inflammatory mechanisms…Gender-dependent behavioral and biochemical differences in the A53T genetic mouse model of Parkinson’s disease
Objective: The main aim of the present study was to investigate whether behavioral and biochemical differences may occur between male and female old (12-month-old) transgenic…Glatiramir acetate (Copaxone) causes restoration of the striatal dopamine in a progressive MPTP mouse model of Parkinson’s disease
Objective: To assess if a microglial modulator, Glatiramer Acetate (GA), can restore loss of striatal dopamine (DA) and behavioral deficits following progressive 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)…Amelioration of αLPHA-synuclein aggregation and motor behavior deficits by apocyanin in intranigral lipopolysaccharide induced animal model of Parkinson’s disease
Objective: The present study evaluated the therapeutic potentials of apocyanin for the treatment of neurobehavioral consequences in LPS induced PD model. Background: Parkinson's disease (PD),…Role of macroautophagy in regulating microglia-mediated neuroinflammation and dopaminergic neuron injury
Objective: To investigate the potential role of macroautophagy in the regulation of microglia-mediated neuroinflammation and dopamine neuron injury. Background: Chronic neuroinflammation, a process mediated by…Lymphocytes have a detrimental effect on motor behavior in the AAV1/2 A53T α-synuclein mouse model of Parkinson’s disease
Objective: To determine the contribution of the adaptive immune system in the pathogenesis of a mouse model of Parkinson's disease (PD) based on AAV1/2 driven…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.