Lrrk2 alleles modify host response to microbial infections
Objective: The mechanisms by which allelic changes in LRRK2 modulate the susceptibility to Parkinson's disease, Crohn's disease and leprosy remain unknown. We hypothesized that leucine-rich…Progression of microglial activation and neuroinflammatory responses in a transgenic mouse model of multiple system atrophy
Objective: Our aim was to characterize the progression of microglial activation during disease progression in a transgenic mouse model of multiple system atrophy (MSA). Background:…Apocyanin ameliorates post-stroke movement disorder in rats: Possible role of neurochemical and inflammatory alterations
Objective: To study the neuroprotective efficacy of apocynin, a NADPH oxidase inhibitor in 1) alterations of post- stroke motor behaviour, 2) alterations of various neurotransmitter…Microglia P2Y6 receptor is related to Parkinson’s disease and involved in the neuroinflammatory process
Objective: To investigate whether the purinoceptor P2Y6 can be used as a biomarker in the diagnosis and treatment of Parkinson's disease (PD) and the role…The inflammatory burden of tic onset in a paediatric cohort: A preliminary study
Objective: To evaluate the role of inflammatory triggering factors in the onset of tics and Tourette syndrome in a prospective cohort of paediatric population. Background:…Leukocyte perturbations suggest immune dysregulation in progressive supranuclear palsy
Objective: Compare the serum cytokine profiles and phenotypes of peripheral blood mononuclear cells (PBMCs) in a patient with Progressive Supranuclear Palsy (PSP) with his healthy…CSF inflammatory and cell death biomarkers in Huntington’s disease – An exploratory cross-sectional study
Objective: This exploratory work intended to study general inflammatory cytokines, microglial activation markers, and neuronal cell death markers in the cerebrospinal fluid (CSF) of HD…Parkinson’s syndrome as possible manifestation of lamina quadrigemina tumor or inflammation
Objective: Objective of this report is to discuss the case of Parkinson's syndrome (PS) in 22 y.o. patient on the background of the pathological process…The role of cathepsin L involved in the activation of microglia and Parkinson’s disease
Objective: To investigate the role of lysosomal protease cathepsin L in the activation of microglia and the injury of dopaminergic neurons, and further to interpret…Inflammatory profile discriminates clinical subtypes in LRRK2-associated PD
Objective: To evaluate whether inflammatory processes in PD patients with mutations in the LRRK2 gene (PD-LRRK2) are associated with modification of clinical features and disease…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.