Salivary Biomarkers in Parkinson’s Disease: A Follow-Up Study
Objective: Investigate longitudinal changes in salivary levels of oligomeric and total a-synuclein (a-syn), phosphorylated-tau (p-tau), total tau, MAP-LC3, and TNFa in Parkinson’s Disease (PD) patientsAssess…Gut Dysbiosis Alters Host Metabolism but Does Not Independently Induce Parkinson’s Disease Pathology
Objective: To determine whether gut dysbiosis alone is sufficient to induce Parkinson’s disease (PD) pathology and to investigate its impact on host metabolism. Background: Gut…Alpha-Synuclein Preformed Fibrils Increase the Frequency of CXCR3+ B-cells in Early-stage Parkinson’s Disease Patients
Objective: To investigate the effect of a-Syn Preformed Fibrils (PFF) on CXCR3 expression on B-cells in Parkinson’s Disease (PD) patients at early (E-PD, diagnosed less…Hyperbaric Oxygen Therapy for Parkinson’s disease via modulation of gut microbiota
Objective: To investigate the effect of hyperbaric oxygen therapy (HBOT) on gut microbiota in a preclinical model of PD. Background: Humans have coevolved with complex…Immune cell changes in early Dementia with Lewy Bodies
Objective: To examine if immune cell changes are present in early stages of Dementia with Lewy Bodies (DLB). Background: Evidence for inflammation in synucleinopathies has…Paeoniflorin Combined with Neural Stem Cell Transplantation for Parkinson’s Disease: Synergistic Effects of Cell Therapy and Inflammation Regulation
Objective: To investigate the feasibility and efficacy of paeoniflorin (PF) combined with neural stem cell (NSC) transplantation in treating Parkinson's disease (PD). Background: Parkinson's disease…Baseline brain inflammation is associated with less cognitive progression at 24 months in subjects with de novo Parkinson’s disease
Objective: To examine if brain inflammation measured by 18F-DPA-714 imaging is associated with cognitive change in subjects with early Parkinson’s disease (PD). Background: Evidence for…Reduced intestinal inflammation and increased levels of short-chain fatty acids thanks to an active lifestyle in Parkinson’s disease.
Objective: This study aimed to determine whether people with Parkinson’s disease (PD) with an active lifestyle had increased production of certain microbial metabolites such as…Inflammation Biomarkers and Free Water Fraction in the Cholinergic Forebrain System in Idiopathic Parkinson’s Disease
Objective: Investigate if inflammatory biomarkers moderate the association between, cholinergic basal forebrain free water fraction and cholinergic innervation in idiopathic Parkinson’s disease. Background: The cholinergic…The Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons with REM Sleep Behavior Disorder (RBD)
Objective: To explore the potential for an immunologically based intervention to slow evolution of symptoms in persons with prodromal or Stage 2b (Simuni et al.…
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