Safety of Iron Chelation in Patients with Brain Iron Overload
Objective: To assess the safety of iron chelation in the treatment of regional brain iron overload. Background: Excess brain iron is evident in neurodegenerative diseases…Iron Supplementation for the Treatment of Restless Legs Syndrome – A Systematic Review and Meta-Analysis
Objective: To gather the evidence for the efficacy and safety of iron supplementation for restless legs syndrome (RLS). Background: Iron supplementation is used for the…Nigral Iron Load as Diagnostic Parameter in Parkinson’s Disease
Objective: The aim of our study was to determine the diagnostic value of nigral iron depositions in PD, measured by iron specific MRI-techniques. Background: Nigral…Restless legs syndrome in a patient with hereditary hemochromatosis
Objective: We present a case with two disorders, hereditary hemochromatosis (HH) and Restless Legs Syndrome (RLS), each related to the two ends of the spectrum…Speculation on the timing of iron deposition in the putamen of patients with multiple system atrophy: multimodal MRI study
Objective: We sought to investigate the temporal pattern of iron deposition in the putamen of patients with multiple system atrophy (MSA) by calculating conditional probabilities…The interaction between iron metabolism and inflammation in Parkinson´s disease: an in vivo and post mortem study
Objective: To assess the relationship iron and inflammatory markers in an in vivo and post mortem study of Parkinson´s disease subjects. Background: Although neuroinflammation and…Caudal posterior substantia nigra iron increases longitudinally in Parkinson’s disease
Objective: To investigate spatial patterns and temporal evolution of substantia nigra (SN) iron accumulation in Parkinson’s disease (PD) using quantitative susceptibility mapping (QSM), an indirect…In vivo increased striatal iron deposition in Parkinson’s Disease Dementia and Dementia with Lewy Body
Objective: To evaluate iron deposition with susceptibility weighted imaging (SWI) MRI in the basal ganglia of patients affected by Parkinson’s Disease Dementia (PDD) and Dementia…PBT434 prevents the accumulation of glial cell inclusions and insoluble alpha-synuclein in a mouse model of Multiple System Atrophy
Objective: To evaluate PBT434 in a transgenic mouse model of multiple system atrophy (MSA) Background: PBT434 is a novel quinazolinone inhibitor of iron-mediated protein accumulation…Seasonal Fluctuation in a Chinese cohort of patients with idiopathic Restless Legs Syndrome
Objective: To evaluate incidence and characteristics of seasonal fluctuation in a Chinese cohort of patients with idiopathic RLS in order to differentiate possible subtypes and…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.