A review of modifiers of Parkinsonism in the Leucine-rich repeat kinase 2 (LRRK2) population
Objective: To review and examine the most current identified modifiers of Parkinsonism in the LRRK2 population. Background: LRRK2 is a protein with multiple domains and…Data driven analysis for exploring phenotypic differences in patients with Parkinson’s disease with or without genetic mutations.
Objective: To explore, using a data driven statistical analysis method, discriminating phenotype features of disease in a large group of patients with Parkinson’s disease (PD)…Gene associated differences in pre-diagnostic symptoms of Parkinson’s Disease: a retrospective study
Objective: To investigate whether glucocerebrosidase (GBA) L444P and leucine-rich repeat kinase 2 (LRRK2) G2385R and R1628P mutations are associated with different symptoms and manifesting patterns…Motor and Nonmotor clinical phenotype in LRRK2 Parkinson’s disease patients: a Case-control study
Objective: Our study aimed to characterize and compare the clinical phenotype of LRRK2-PD patients with PD patients with no identified mutations. Background: The clinical phenotype…Altered intrinsic brain functional connectivity in drug-naïve Parkinson’s disease with LRRK2 mutation
Objective: This study aimed to compare the alterations in the cortico-striatal functional connectivity (FC) of drug-naïve Parkinson’s disease (PD) patients with the leucine-rich repeat kinase…The influence of LRRK2 mutations on cholinergic system in manifest and prodromal stage of Parkinson’s disease: a positron emission tomography study
Objective: To evaluate the effects of leucine-rich repeat kinase 2 (LRRK2) mutations on the central cholinergic system in both manifesting and non-manifesting carriers using PET…Impaired stress-induced mitophagy in parkinsonian LRRK2(R1441G) knockin mutant mice
Objective: 1. Morphological changes and accumulation of ubiquitinated mitochondria in the striatum of aged leucine-rich-repeat kinase 2 (LRRK2)R1441G knockin mutant mice (Liu et al., 2014,…Understanding the role of LRRK2 in Indian population
Objective: Genomic approaches in Caucasian population show little transferability to other ethnically diverse populations such as Indian population. Understanding the genetic architecture of a disease…Assessing the response to L-dopa/carbidopa intestinal gel infusion (Deudopa) based on genetic status.
Objective: To asses genetic impact on dosage of L-dopa/carbidopa treatment Background: L-dopa/carbidopa intestinal gel infusion (LCIG) is a method of continuous dopaminergic stimulation used in…Comparison of the non-motor symptom assessment scale between LRRK2 G2019S positive versus matched control Parkinson disease
Objective: To compare the non-motor symptom assessment scale (NMSS) score between Leucine-rich repeat kinase 2 (LRRK2) mutation carriers with Parkinson disease (PD) and matched controls with…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.