Articles tagged "Lipid metabolism"

2017 International Congress
Elevated GM3 Plasma Concentration in Idiopathic Parkinson’s Disease: a Lipidomics Analysis
R. Alcalay, R. Chan, C. Liong, A. Perotte, B. Zhou, E. Shorr, K. Marder, U. Kang, C. Waters, O. Levy, Y. Xu, H. Shim, I. Pe'er, G. Di Paolo (New York, NY, USA)
Objective: To test the association between plasma lipids and Parkinson disease (PD) diagnosis. Background: PD is a common neurodegenerative disease whose pathological hallmark is the…
2016 International Congress
Mitochondrial cardiolipin couples electron transport between ubiquinone and complex I to rescue PINK1 deficiency
M. Vos, A. Geens, L. Deaulmerie, J. Swerts, K. Craessaerts, P. Seibler, A. Rakovic, B. De Strooper, R. Efremov, V.A. Morais, C. Klein, P. Verstreken (Lübeck, Germany)
Objective: Test the effect of loss of FASN on Pink1 deficiency. Background: PINK1 deficiency causes Parkinson's disease that is based on mitochondrial defects including inefficient…
2016 International Congress
Coding and non-coding glucocerebrosidase variants have an impact on cognitive decline in Parkinson’s disease
C. Schulte, I. Liepelt-Scarfone, C.E. Hagen, A.K. Hauser, K. Brockmann, T. Gasser, J.B. Schulz, K. Reetz, S. Gräber, B. Mollenhauer, C. Trenkwalder, K. Witt, N. Schmidt, R. Dodel, M. Balzer-Geldsetzer, U. Wüllner, T. Klockgether, A. Spottke, A. Storch, H.U. Wittchen, O. Riedel, S. Baudrexel, E. Kalbe, D. Berg, M.M. Mielke (Tübingen, Germany)
Objective: To evaluate the impact of genetic variants in the Glucocerebrosidase gene (GBA) on cognitive impairment in a large cohort of Parkinson's disease (PD) patients…
2016 International Congress
Molecular landscape of Parkinson’s disease reveals a key role for lipids and lipoproteins
C.J.H.M. Klemann, G.J.M. Martens, M. Sharma, M.B. Martens, O. Isacson, T. Gasser, J.E. Visser, G. Poelmans (Nijmegen, Netherlands)
Objective: Integrate available genetic and expression data to generate a molecular landscape of Parkinson's disease (PD) in order to identify key disease mechanisms that may…
2016 International Congress
The association between structural brain connectivity with plasma APO-A1 levels in Parkinson’s disease: Connectometry approach
F. Rahmani, M.H. Aarabi (Tehran, Islamic Republic of Iran)
Objective: Features of the lipid profile specially cholesterol levels are association with PD risk. However no such data exists on the association of these plasma…
2016 International Congress
Plasma ceramides and glucosylceramides predict cognitive decline among cognitively normal Parkinson’s disease patients
M.M. Mielke, C.E. Hagen, R. Savica, J.A. Syrjanen, X.M.T. Persson, C. Schulte, R. Dodel, M. Balzer-Geldsetzer, J.B. Schulz, K. Reetz, U. Wullner, A. Spottke, A. Storch, H.U. Wittchen, O. Riedel, E. Kalbe, S. Graber-Sultan, T. Gasser, D. Berg, I. Liepelt-Scarfone (Rochester, MN, USA)
Objective: To determine whether plasma ceramides, glucosylceramides, and their ratios predict cognitive decline among cognitively normal Parkinson's disease (PD) patients. Background: There are no biomarkers…
2016 International Congress
Adult onset Niemann-Pick type C: 24 month follow-up on miglustat
B. Elibol, F. Ozkinay, H. Onder (Ankara, Turkey)
Objective: To present a rare case of adult onset NPC patient and pointing out varying response of her distinct symptoms on long term follow up…
2016 International Congress
Biochemical features of lipids spectrum in blood in patients with Parkinson’s disease
Z.A. Akbarkhodjaeva, F. Saidvaliev (Tashkent, Uzbekistan)
Objective: To study characteristic of lipid levels in patients with PD. Background: Currently, there is no clear data about the features of lipid metabolism in…