Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors
Objective: In this study we aim to elucidate the role of Kif5b motor subunit in the nigrostriatal pathway. We have generated different conditional knockout mice…Structural neural correlates of independent gait domains in Parkinson’s disease
Objective: To assess the subcortical motor structures of the brain associated with independent gait domains from Lord et al’s gait models (1, 2), in Parkinson’s…Return to automaticity: cortical activity during gait in Parkinson’s disease
Objective: This study investigated pre-frontal cortex (PFC) activation while walking in older adults and people with Parkinson’s disease (PD). We specifically examined 1) PFC activation…Dynamic Instability and Stride Width in Parkinsonism
Objective: To compare differences in local dynamic stability (LDS) and its association with stride width in individuals with idiopathic Parkinson’s Disease (iPD), individuals with frontal…D2 receptor mediated DARPP32/PP1α signaling is responsible for cadmium induced Parkinson’s like behavioral alterations in rats
Objective: To identify the specificity of dopamine D2 receptor mediated signaling in cadmium mediated motor alterations Background: Cadmium, a heavy metal, is to known to…Instrumental Measurement of Stepping in Place – Detection of Asymmetry and Freezing of Gait
Objective: To detect freezing of gait (FoG) and quantify movement asymmetry from markerless full body motion capture with Microsoft Kinect™ during the execution of a…Predictive Ability of Clinical Timed Tests for Postural Instability and Gait Difficulty in Parkinson’s Disease
Objective: To identify clinical determinants for postural instability and gait difficulty in persons with Parkinson's disease (PD). Background: Gait deficits and postural instability in persons…The combination of clinical scales and walking measures to predict falls in Parkinson’s disease: Does the length of the prospective follow-up period matter?
Objective: This study aimed: (i) to identify the best combination of clinical scales and walking measures to predict falls in people with Parkinson’s disease (PD)…Management of fragility fractures in Parkinson’s Disease (PD)
Objective: To assess the management of osteoporotic fragility fractures in patients with PD attending a Movement disorders clinic. Background: Patients with PD have a high…Falls characteristics of male and female patients with Parkinson’s disease (PD)
Objective: To compare Falls risk characteristics in male and female PD patients attending a multidisciplinary Movement disorders clinic. Background: Parkinson’s disease is commoner in males.…
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